Neuron-Specific Class III Beta-Tubulin (TUBB3) Antibody

Name: TUBB3 Antibody; MyBioSource
Brand: MyBioSource
SKU: MBS850425
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS850425

Tubulin is a compound of subunits of A tubulin and B tubulin. Class III beta tubulin (beta III-tubulin) is a vertebrate tubulin isotype specific to the neurons and mammalian testis cells, making it an ideal neuronal marker. Overexpression of class III beta… More details

$430 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neuron-specific class III beta-tubulin (TUBB3), Antibody

Full Product Name

Neuron-specific class III beta-tubulin Antibody

Product Gene Name

anti-TUBB3 antibody

Clone Number

A8-D10

Species Reactivity

Human, Mouse, Rat

Form/Format

In 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.

Specificity

This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to the near of N-terminal residues of neuro-specific class III beta-tubulin.

Preparation and Storage

Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

Molecular Weight

50kDa

OMIM

600638

3D Structure

ModBase 3D Structure for Q13509

Preservative

0.05% Sodium Azide.

Positive Control

Hela

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-TUBB3 antibody

Western Blot (WB)

Application Notes for anti-TUBB3 antibody

WB: 1:5,000

Product References and Citations for anti-TUBB3 antibody

1. Wang, HW et al. Nature 435: 911-915, 2005. 2. Cleveland, DW et al. Cell 20: 95-105, 1980. 3. Hasegawa S et al. Clin Can Res 9: 2992-2997, 2003.

Other Notes

Small volumes of anti-TUBB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TUBB3 purchase

MBS850425 is an antibody targeting TUBB3. Also known as Neuron-specific class III beta-tubulin Antibody. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for TUBB3. It may not necessarily be applicable to this product.

NCBI GI #

308235963

NCBI GeneID

10381

NCBI Accession #

NP_001184110.1

UniProt Primary Accession #

Q13509

UniProt Secondary Accession #

Q9BTZ0; Q9BW10; A8K854

UniProt Related Accession #

Q13509

GenBank Nucleotide #

NM_001197181.1

NCBI Official Full Name

tubulin beta-3 chain isoform 2

NCBI Official Synonym Full Names

tubulin beta 3 class III

NCBI Official Symbol

TUBB3

NCBI Official Synonym Symbols

CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A

UniProt Protein Name

Tubulin beta-3 chain

UniProt Synonym Protein Names

Tubulin beta-4 chain; Tubulin beta-III

Protein Family

Tubulin

UniProt Gene Name

TUBB3

UniProt Synonym Gene Names

TUBB4

NCBI Protein Information

tubulin beta-3 chain

NCBI Summary for TUBB3

This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]

UniProt Comments for TUBB3

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.

Research Articles on TUBB3

1. The miR-34a/STMN1/betaIII-tubulin axis maintains the microtubule cytoskeleton in osteosarcoma, and combining miR-34a with microtubule inhibitors can be investigated as a novel therapeutic strategy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TUBB3 antibody

Products by Pathway	Pathway Diagram
Chaperonin-mediated Protein Folding Pathway antibodies	Chaperonin-mediated Protein Folding Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies	Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies	Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies	Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gap Junction Pathway antibodies	Gap Junction Pathway Diagram
Gap Junction Pathway antibodies	Gap Junction Pathway Diagram

Diseases associated with anti-TUBB3 antibody

Disease Name	Pubmed Publications
Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement Antibodies	>514 publications with TUBB3 and Fibrosis Of Extraocular Muscles, Congenital, 3A, with or without Extraocular Involvement
Neoplasms Antibodies	>47 publications with TUBB3 and Neoplasms
Nervous System Diseases Antibodies	>16 publications with TUBB3 and Nervous System Diseases
Ovarian Neoplasms Antibodies	>12 publications with TUBB3 and Ovarian Neoplasms
Breast Neoplasms Antibodies	>9 publications with TUBB3 and Breast Neoplasms
Fibrosis Antibodies	>8 publications with TUBB3 and Fibrosis
Neoplasms, Experimental Antibodies	>5 publications with TUBB3 and Neoplasms, Experimental
Brain Diseases Antibodies	>4 publications with TUBB3 and Brain Diseases
Carcinoma, Squamous Cell Antibodies	>4 publications with TUBB3 and Carcinoma, Squamous Cell
Eye Diseases Antibodies	>4 publications with TUBB3 and Eye Diseases

Organs/Tissues associated with anti-TUBB3 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>22 publications with TUBB3 and Lung
Brain Antibodies	>20 publications with TUBB3 and Brain
Nerve Antibodies	>10 publications with TUBB3 and Nerve
Muscle Antibodies	>9 publications with TUBB3 and Muscle
Eye Antibodies	>9 publications with TUBB3 and Eye
Heart Antibodies	>8 publications with TUBB3 and Heart
Embryonic Tissue Antibodies	>6 publications with TUBB3 and Embryonic Tissue
Testis Antibodies	>4 publications with TUBB3 and Testis
Lymph Antibodies	>3 publications with TUBB3 and Lymph
Lymph Node Antibodies	>3 publications with TUBB3 and Lymph Node