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TAB2 Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS850652

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TAB2, Antibody
Full Product Name
TAB2 Antibody
Product Gene Name
anti-TAB2 antibody
Product Synonym Names
CHTD2; FLJ21885; KIAA0733; MAP3K7IP2; TAB2
Isotype
IgG1
Clone Number
3B5
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C.
Molecular Weight
80kDa
OMIM
605101
3D Structure
ModBase 3D Structure for Q9NYJ8
Immunogen
Purified recombinant fragment of human TAB2 expressed in E. Coli.

Product Categories/Family for anti-TAB2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TAB2 antibody
Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)
Application Notes for anti-TAB2 antibody
WB: 1:500-1:2000
FC: 1:200-1:400
ELISA: 1:10000

Western Blot (WB) of anti-TAB2 antibody

Figure 1: Western blot analysis using TAB2 mAb against HEK293 (1) and TAB2-hIgGFc transfected HEK293 (2) cell lysate.
Mouse Anti-TAB2 Antibody – Cat# MBS850652

Flow Cytometry (FC/FACS) of anti-TAB2 antibody

Figure 2: Flow cytometric analysis of HL-60 cells using TAB2 mouse mAb (green) and negative control (purple).
Mouse Anti-TAB2 Antibody, Flow Cytometry (FC/FACS) – Cat# MBS850652

Other Notes

Small volumes of anti-TAB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAB2 purchase

MBS850652 is an antibody targeting TAB2. Also known as TAB2 Antibody. Reactive in Human, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TAB2. It may not necessarily be applicable to this product.

NCBI GI #
14149669
NCBI GeneID
23118
NCBI Accession #
NP_055908.1
UniProt Primary Accession #
Q9NYJ8
UniProt Secondary Accession #
O94838; Q6I9W8; Q76N06; Q9UFP7; B2RCC4; E1P5A0
UniProt Related Accession #
Q9NYJ8
GenBank Nucleotide #
NM_015093.5
NCBI Official Full Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a
NCBI Official Synonym Full Names
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
NCBI Official Symbol
TAB2
NCBI Official Synonym Symbols
CHTD2; TAB-2; MAP3K7IP2
UniProt Protein Name
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
UniProt Synonym Protein Names
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2
Protein Family
TGF-beta-activated kinase 1 and MAP3K7-binding protein
UniProt Gene Name
TAB2
UniProt Synonym Gene Names
KIAA0733; MAP3K7IP2; TAB-2
NCBI Protein Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

NCBI Summary for TAB2

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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UniProt Comments for TAB2

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

Research Articles on TAB2

1. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 signaling as a novel pathogenic substrate for polyvalvular syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TAB2 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 FCERI Mediated NF-kB Activation Pathway antibodies  FCERI Mediated NF-kB Activation Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram

Diseases associated with anti-TAB2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >51 publications with TAB2 and Necrosis
 Liver Diseases Antibodies  >9 publications with TAB2 and Liver Diseases
 Abnormalities, Multiple Antibodies  >6 publications with TAB2 and Abnormalities, Multiple
 Carcinoma, Hepatocellular Antibodies  >3 publications with TAB2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with TAB2 and Liver Neoplasms
 Ataxia Antibodies  >2 publications with TAB2 and Ataxia
 Nervous System Diseases Antibodies  >2 publications with TAB2 and Nervous System Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with TAB2 and Drug-Related Side Effects and Adverse Reactions
 Fetal Death Antibodies  >2 publications with TAB2 and Fetal Death
 Drug-Induced Liver Injury Antibodies  >2 publications with TAB2 and Drug-Induced Liver Injury

Organs/Tissues associated with anti-TAB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with TAB2 and Blood
 Bone Antibodies  >13 publications with TAB2 and Bone
 Liver Antibodies  >12 publications with TAB2 and Liver
 Bone Marrow Antibodies  >8 publications with TAB2 and Bone Marrow
 Vascular Antibodies  >6 publications with TAB2 and Vascular
 Kidney Antibodies  >5 publications with TAB2 and Kidney
 Skin Antibodies  >5 publications with TAB2 and Skin
 Brain Antibodies  >5 publications with TAB2 and Brain
 Eye Antibodies  >4 publications with TAB2 and Eye
 Heart Antibodies  >4 publications with TAB2 and Heart
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