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Dynamin-1 (DNM1) Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS850741

Dynamin-1 (Dyn1), with 864-amino acid protein (about 95kDa), belongs to the dynamin family. Dynamin-1 (neuron-specific), dynamin-2 (ubiquitously expressed), and dynamin-3 (expressed only in the testis, brain, and lung), constitute the dynamin family. Members… More details

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Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Dynamin-1 (DNM1), Antibody
Full Product Name
Dynamin-1 Antibody
Product Gene Name
anti-DNM1 antibody
Product Synonym Names
ECK; EPHA2
Isotype
IgG2a
Clone Number
3G4B6
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C
Molecular Weight
95,895 Da
OMIM
602377
3D Structure
ModBase 3D Structure for Q05193
Immunogen
Purified recombinant fragment of human Dynamin-1 expressed in E. Coli.

Product Categories/Family for anti-DNM1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DNM1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-DNM1 antibody
WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-DNM1 antibody

Figure 1. Western blot analysis using Dynamin1 mouse mAb against C6 (1), NIH/3T3 (2), SKN-SH (3), LN18 (4), SHSY5Y (5) cell lysate and rat brain tiisues lysate (6).
Mouse Anti-DNM1 Antibody – Cat# MBS850741

Immunohistochemistry (IHC) of anti-DNM1 antibody

Figure 2. Immunohistochemical analysis of paraffin-embedded human lymph tissue (A), glioma tissue (B) and cerebellum tissue (C), showing membrane localization using Dynamin1 mouse mAb with DAB staining
Mouse Anti-DNM1 Antibody, Immunohistochemistry (IHC) – Cat# MBS850741

Other Notes

Small volumes of anti-DNM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNM1 purchase

MBS850741 is an antibody targeting DNM1. Also known as Dynamin-1 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DNM1. It may not necessarily be applicable to this product.

NCBI GI #
56549117
NCBI GeneID
1759
NCBI Accession #
NP_001005336.1
UniProt Primary Accession #
Q05193
UniProt Secondary Accession #
Q5SYX0; Q5SYX2; Q6P3T6; Q86VD2; A6NLM6
UniProt Related Accession #
Q05193
GenBank Nucleotide #
NM_001005336.2
NCBI Official Full Name
dynamin-1 isoform 2
NCBI Official Synonym Full Names
dynamin 1
NCBI Official Symbol
DNM1
NCBI Official Synonym Symbols
DNM; EIEE31
UniProt Protein Name
Dynamin-1
Protein Family
Dynamin
UniProt Gene Name
DNM1
UniProt Synonym Gene Names
DNM
NCBI Protein Information
dynamin-1

NCBI Summary for DNM1

This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for DNM1

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.

Research Articles on DNM1

1. Dynamin isoforms differentially regulate the endocytosis and apoptotic signaling downstream of TRAIL-death receptor (TRAIL-DR) complexes in cancer cells. TRAIL stimulation activates ryanodine receptor-mediated calcium release from endoplasmic reticulum stores, leading to calcineurin-mediated dephosphorylation and activation of Dyn1, TRAIL-DR endocytosis, and increased resistance to TRAIL-induced apoptosis.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DNM1 antibody

 Reference Product  PubMed Publications
 SNAP25 antibody  >2 publications with DNM1 and SNAP25
 SH3GL3 antibody  >1 publications with DNM1 and SH3GL3
 SH3GL2 antibody  >1 publications with DNM1 and SH3GL2
 SH3GL1 antibody  >1 publications with DNM1 and SH3GL1
 BIN1 antibody  >1 publications with DNM1 and BIN1

Pathways associated with anti-DNM1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram

Diseases associated with anti-DNM1 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with DNM1 and Brain Diseases
 Dog Diseases Antibodies  >3 publications with DNM1 and Dog Diseases
 Mental Disorders Antibodies  >2 publications with DNM1 and Mental Disorders
 Kidney Diseases Antibodies  >2 publications with DNM1 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with DNM1 and Fibrosis
 Memory Disorders Antibodies  >1 publications with DNM1 and Memory Disorders
 Cognition Disorders Antibodies  >1 publications with DNM1 and Cognition Disorders
 Neurobehavioral Manifestations Antibodies  >1 publications with DNM1 and Neurobehavioral Manifestations

Organs/Tissues associated with anti-DNM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >8 publications with DNM1 and Nerve
 Muscle Antibodies  >6 publications with DNM1 and Muscle
 Brain Antibodies  >4 publications with DNM1 and Brain
 Kidney Antibodies  >3 publications with DNM1 and Kidney
 Embryonic Tissue Antibodies  >2 publications with DNM1 and Embryonic Tissue
 Testis Antibodies  >1 publications with DNM1 and Testis
 Eye Antibodies  >1 publications with DNM1 and Eye
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