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MSH2 Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS850999

MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to… More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MSH2, Antibody
Full Product Name
MSH2 Antibody
Product Gene Name
anti-MSH2 antibody
Product Synonym Names
FCC1; COCA1; HNPCC; LCFS2
Isotype
IgG1
Clone Number
1B3=3A2B8C
Host
Mouse
Species Reactivity
Human, Monkey
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C
Molecular Weight
105kDa
OMIM
159552
3D Structure
ModBase 3D Structure for Q07820
Immunogen
Purified recombinant fragment of human MSH2 expressed in E. Coli.

Product Categories/Family for anti-MSH2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MSH2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-MSH2 antibody
WB: 1:500-1:2000
IHC: 1:200-1:1000
IF: 1:200-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-MSH2 antibody

Figure 1. Western blot analysis using MSH2 mouse mAb against Hela (1), A549 (2), A431 (3) and HEK293 (4) cell lysate.
Mouse Anti-MSH2 Antibody – Cat# MBS850999

Immunohistochemistry (IHC) of anti-MSH2 antibody

Figure 2. Immunohistochemical analysis of paraffin-embedded human breast cancer (left) and lung cancer (right) tissues, showing nuclear localization using MSH2 mouse mAb with DAB staining.
Mouse Anti-MSH2 Antibody, Immunohistochemistry (IHC) – Cat# MBS850999

Immunofluorescence (IF) of anti-MSH2 antibody

Figure 3. Confocal immunofluorescence analysis of Hela (left) and NTERA-2 (right) cells using NPM mouse mAb (green). Red. Actin filaments have been labeled with DY-554 phalloidin.
Mouse Anti-MSH2 Antibody, Immunofluorescence (IF) – Cat# MBS850999

Other Notes

Small volumes of anti-MSH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MSH2 purchase

MBS850999 is an antibody targeting MSH2. Also known as MSH2 Antibody. Reactive in Human, Monkey. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MSH2. It may not necessarily be applicable to this product.

NCBI GI #
309747067
NCBI GeneID
4170
NCBI Accession #
NP_001184249.1
UniProt Primary Accession #
Q07820
UniProt Secondary Accession #
Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1; B2R6B2; D3DV03; D3DV04
UniProt Related Accession #
Q07820
GenBank Nucleotide #
NM_001197320.1
NCBI Official Full Name
induced myeloid leukemia cell differentiation protein Mcl-1 isoform 3
NCBI Official Synonym Full Names
MCL1, BCL2 family apoptosis regulator
NCBI Official Symbol
MCL1
NCBI Official Synonym Symbols
TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT
UniProt Protein Name
Induced myeloid leukemia cell differentiation protein Mcl-1
UniProt Synonym Protein Names
Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
Protein Family
DNA mismatch repair protein
UniProt Gene Name
MCL1
UniProt Synonym Gene Names
BCL2L3; Bcl2-L-3
NCBI Protein Information
induced myeloid leukemia cell differentiation protein Mcl-1

NCBI Summary for MSH2

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
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UniProt Comments for MSH2

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Research Articles on MSH2

1. Our findings suggest FBW7 mutational status and Mcl-1 stability as key determinants of response to Hsp90 inhibitors, which provides a rationale for using FBW7 genotype for potential patient stratification, and for drug combinations with Hsp90 inhibitors that can effectively overcome Mcl-1-mediated resistance.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MSH2 antibody

 Reference Product  PubMed Publications
 BAX antibody  >41 publications with MSH2 and BAX
 CASP3 antibody  >33 publications with MSH2 and CASP3
 BCL2L1 antibody  >33 publications with MSH2 and BCL2L1
 PMAIP1 antibody  >9 publications with MSH2 and PMAIP1
 BID antibody  >8 publications with MSH2 and BID
 BAD antibody  >8 publications with MSH2 and BAD
 BAK1 antibody  >7 publications with MSH2 and BAK1
 BIK antibody  >5 publications with MSH2 and BIK
 BBC3 antibody  >5 publications with MSH2 and BBC3
 PCNA antibody  >5 publications with MSH2 and PCNA

Pathways associated with anti-MSH2 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-MSH2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >133 publications with MSH2 and Neoplasms
 Multiple Myeloma Antibodies  >15 publications with MSH2 and Multiple Myeloma
 Drug Toxicity Antibodies  >13 publications with MSH2 and Drug Toxicity
 Lung Diseases Antibodies  >12 publications with MSH2 and Lung Diseases
 Necrosis Antibodies  >11 publications with MSH2 and Necrosis
 Adenocarcinoma Antibodies  >10 publications with MSH2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >10 publications with MSH2 and Lung Neoplasms
 Nervous System Diseases Antibodies  >6 publications with MSH2 and Nervous System Diseases
 Liver Diseases Antibodies  >5 publications with MSH2 and Liver Diseases
 Sarcoma Antibodies  >5 publications with MSH2 and Sarcoma

Organs/Tissues associated with anti-MSH2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >38 publications with MSH2 and Blood
 Bone Antibodies  >22 publications with MSH2 and Bone
 Lung Antibodies  >19 publications with MSH2 and Lung
 Bone Marrow Antibodies  >14 publications with MSH2 and Bone Marrow
 Vascular Antibodies  >12 publications with MSH2 and Vascular
 Brain Antibodies  >10 publications with MSH2 and Brain
 Liver Antibodies  >6 publications with MSH2 and Liver
 Lymph Node Antibodies  >6 publications with MSH2 and Lymph Node
 Lymph Antibodies  >5 publications with MSH2 and Lymph
 Heart Antibodies  >5 publications with MSH2 and Heart
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