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P70 S6 Kinase Beta (p70-S6KB) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851046

MBS851046 is an antibody targeting p70-S6KB. Also known as p70 S6 KinaseBeta (Phospho-Ser423) Antibody. Reactive in Human (Identities = 100%, Positives = 100%); Mouse (Identities = 84%, Positives = 92%). More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
p70 S6 Kinase beta (p70-S6KB), Antibody
Full Product Name
p70 S6 KinaseBeta (Phospho-Ser423) Antibody
Product Gene Name
Product Synonym Names
14 beta; 70 kDa ribosomal protein S6 kinase 2; EC 2.7.11.1; kinase p70S6K-beta; KS6B2; p70 ribosomal S6 kinase beta; p70 S6Kbeta; p70-S6KB; p70S6K-beta; Ribosomal protein S6 kinase beta 2; RPS6KB2; S6 kinase-related kinase; S6K-beta 2; S6K2; SRK; STK14B
Species Reactivity
Human (Identities = 100%, Positives = 100%); Mouse (Identities = 84%, Positives = 92%)
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Concentration
1mg/ml (lot specific)
Specificity
p70 S6 Kinase Beta (Phospho-Ser423) antibody detects endogenous levels of p70 S6 Kinase Beta only when phosphorylated at serine 423.
Preparation and Storage
Store at -20 degree C/1 year.
OMIM
608939
3D Structure
ModBase 3D Structure for Q9UBS0
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human p70 S6 Kinase beta around the phosphorylation site of serine 423 (P-V-SP-P-L).
All Sites
Human: Ser423
Mouse: Ser423
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-p70-S6KB antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-p70-S6KB antibody
WB: 1:500~1:1000
ELISA: 1:1000

Western Blot (WB) of anti-p70-S6KB antibody

Western blot analysis of extracts from K562 cells, treated with EGF (200ng/ml, 5mins), using p70 S6 Kinase Beta (Phospho-Ser423) antibody.
Anti-p70-S6KB Antibody – Cat# MBS851046

Immunofluorescence (IF) of anti-p70-S6KB antibody

Immunofluorescence analysis of HeLa cells, using Cytokeratin 8 (Phoshpho-Ser431) antibody.
Anti-p70-S6KB Antibody, Immunofluorescence (IF) – Cat# MBS851046

Product References and Citations for anti-p70-S6KB antibody

Gout I., J. Biol. Chem. 273:30061-30064(1998). Saitoh M., Biochem. Biophys. Res. Commun. 253:470-476(1998). Lee-Fruman K.K., Oncogene 18:5108-5114(1999).

Other Notes

Small volumes of anti-p70-S6KB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for p70-S6KB. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ribosomal protein S6 kinase beta-2
NCBI Official Synonym Full Names
ribosomal protein S6 kinase B2
NCBI Official Symbol
RPS6KB2
NCBI Official Synonym Symbols
KLS; SRK; S6K2; S6KB; STK14B; S6KI(2); S6Kbeta; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta
UniProt Protein Name
Ribosomal protein S6 kinase beta-2
UniProt Synonym Protein Names
70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70-beta
UniProt Gene Name
RPS6KB2
UniProt Synonym Gene Names
STK14B; S6K-beta-2; S6K2; P70S6K2; p70-S6K 2; SRK; S6K-beta; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70-beta
NCBI Protein Information
ribosomal protein S6 kinase beta-2

NCBI Summary for p70-S6KB

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
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UniProt Comments for p70-S6KB

Phosphorylates specifically ribosomal protein S6.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-p70-S6KB antibody

 Reference Product  PubMed Publications
 MTOR antibody  >6 publications with p70-S6KB and MTOR
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