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MYLIP Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851063

MBS851063 is an antibody targeting MYLIP. Also known as MYLIP Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MYLIP, Antibody
Full Product Name
MYLIP Antibody
Product Gene Name
Product Synonym Names
E3 ubiquitin-protein ligase MYLIP; EC 6.3.2.-; Myosin regulatory light chain-interacting protein; MIR; MYLIP; BZF1; BM-023; PP5242
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
MYLIP antibody detects endogenous levels of total MYLIP protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
14,989 Da
OMIM
610082
3D Structure
ModBase 3D Structure for Q8WY64
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human MYLIP.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MYLIP antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-MYLIP antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000

Testing Data of anti-MYLIP antibody

Peptide-+
Anti-MYLIP Antibody – Cat# MBS851063

Immunohistochemistry (IHC) of anti-MYLIP antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using MYLIP antibody. Western blot analysis of extracts from HeLa cells and Jurkat cells, using MYLIP antibody.
Anti-MYLIP Antibody, Immunohistochemistry (IHC) – Cat# MBS851063

Product References and Citations for anti-MYLIP antibody

Olsson P.-A., J. Biol. Chem. 274:36288-36292(1999). Shi W., Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases. Zhang Q.-H., Genome Res. 10:1546-1560(2000).

Other Notes

Small volumes of anti-MYLIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MYLIP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
E3 ubiquitin-protein ligase MYLIP
NCBI Official Synonym Full Names
myosin regulatory light chain interacting protein
NCBI Official Symbol
MYLIP
NCBI Official Synonym Symbols
MIR; IDOL
UniProt Protein Name
E3 ubiquitin-protein ligase MYLIP
UniProt Synonym Protein Names
Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein; MIR; RING-type E3 ubiquitin transferase MYLIPCurated
UniProt Gene Name
MYLIP
UniProt Synonym Gene Names
BZF1; IDOL; Idol; MIR
NCBI Protein Information
E3 ubiquitin-protein ligase MYLIP

NCBI Summary for MYLIP

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
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UniProt Comments for MYLIP

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYLIP antibody

 Reference Product  PubMed Publications
 CNPY2 antibody  >2 publications with MYLIP and CNPY2
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