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5-HT-6 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851455

MBS851455 is an antibody targeting 5-HT-6. Also known as 5-HT-6 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
5-HT-6, Antibody
Full Product Name
5-HT-6 Antibody
Product Gene Name
Product Synonym Names
5-HT6; 5HT6R; HTR6
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
5-HT-6 antibody detects endogenous levels of total 5-HT-6 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
46,954 Da
OMIM
601109
3D Structure
ModBase 3D Structure for P50406
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human 5-HT-6.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-5-HT-6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-5-HT-6 antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-5-HT-6 antibody

Western blot analysis of extracts from A549 cells, using 5-HT-6 antibody.
Anti-5-HT-6 Antibody – Cat# MBS851455

Product References and Citations for anti-5-HT-6 antibody

Kohen R., J. Neurochem. 66:47-56(1996). Kopatz S.A., Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. Gregory S.G., Nature 441:315-321(2006).

Other Notes

Small volumes of anti-5-HT-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for 5-HT-6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
5-hydroxytryptamine receptor 6
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 6
NCBI Official Symbol
HTR6
NCBI Official Synonym Symbols
5-HT6; 5-HT6R
UniProt Protein Name
5-hydroxytryptamine receptor 6
UniProt Synonym Protein Names
Serotonin receptor 6
UniProt Gene Name
HTR6
UniProt Synonym Gene Names
5-HT-6; 5-HT6
NCBI Protein Information
5-hydroxytryptamine receptor 6

NCBI Summary for 5-HT-6

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
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UniProt Comments for 5-HT-6

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (). Is an activator of TOR signaling (PubMed:23027611).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-5-HT-6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with 5-HT-6 and Brain
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