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ICK Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851572

MBS851572 is an antibody targeting ICK. Also known as ICK (Ab-159) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ICK, Antibody
Full Product Name
ICK (Ab-159) Antibody
Product Gene Name
Product Synonym Names
EC 2.7.11.22; hICK; ICK; Intestinal cell kinase; KIAA0936; kinase ICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK; Serine/threonine kinase ICK
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
ICK (Ab-159) antibody detects endogenous levels of total ICK protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
34,071 Da
OMIM
612325
3D Structure
ModBase 3D Structure for Q9UPZ9
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human ICK around the phosphorylation site of tyrosine 159 (T-D-YP-V-S).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ICK antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ICK antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-ICK antibody

Western blot analysis of extracts from 3T3 cells, treated with PBS (10uM, 60mins), using ICK (Ab-159) antibody.
Anti-ICK Antibody – Cat# MBS851572

Product References and Citations for anti-ICK antibody

Togawa K., J. Cell. Physiol. 183:129-139(2000). Yang T., Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases. Nagase T., DNA Res. 6:63-70(1999).

Other Notes

Small volumes of anti-ICK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ICK. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
serine/threonine-protein kinase ICK
NCBI Official Synonym Full Names
intestinal cell kinase
NCBI Official Symbol
ICK
NCBI Official Synonym Symbols
ECO; MRK; LCK2; EJM10
UniProt Protein Name
Serine/threonine-protein kinase ICK
UniProt Synonym Protein Names
Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK
UniProt Gene Name
ICK
UniProt Synonym Gene Names
KIAA0936; hICK; LCK2; MRK
NCBI Protein Information
serine/threonine-protein kinase ICK

NCBI Summary for ICK

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for ICK

Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (). May play a key role in the development of multiple organ systems and particularly in cardiac development (). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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