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PE2R4 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851577

MBS851577 is an antibody targeting PE2R4. Also known as PE2R4 Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PE2R4, Antibody
Full Product Name
PE2R4 Antibody
Product Gene Name
anti-PE2R4 antibody
Product Synonym Names
Prostaglandin E2 receptor EP4 subtype; PGE receptor; EP4 subtype; Prostanoid EP4 receptor; PTGER4; PTGER2
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
PE2R4 antibody detects endogenous levels of total PE2R4 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
53,119 Da
OMIM
601586
3D Structure
ModBase 3D Structure for P35408
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human PE2R4.

Product Categories/Family for anti-PE2R4 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PE2R4 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-PE2R4 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:5000

Testing Data of anti-PE2R4 antibody

Anti-PE2R4 Antibody – Cat# MBS851577

Western Blot (WB) of anti-PE2R4 antibody

Peptide-+ Western blot analysis of extracts from COLO205 cells, using PE2R4 antibody. Immunofluorescence analysis of MCF-7 cells, using PE2R4 antibody.
Anti-PE2R4 Antibody, Western Blot (WB) – Cat# MBS851577

Product References and Citations for anti-PE2R4 antibody

Bastien L., J. Biol. Chem. 269:11873-11877(1994). An S., Biochem. Biophys. Res. Commun. 197:263-270(1993). Foord S.M., Genomics 35:182-188(1996).

Other Notes

Small volumes of anti-PE2R4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PE2R4. It may not necessarily be applicable to this product.

NCBI GI #
4506259
NCBI GeneID
5734
NCBI Accession #
NP_000949.1
UniProt Primary Accession #
P35408
UniProt Secondary Accession #
Q3MJ87
UniProt Related Accession #
P35408
GenBank Nucleotide #
NM_000958.2
NCBI Official Full Name
prostaglandin E2 receptor EP4 subtype
NCBI Official Synonym Full Names
prostaglandin E receptor 4
NCBI Official Symbol
PTGER4
NCBI Official Synonym Symbols
EP4; EP4R
UniProt Protein Name
Prostaglandin E2 receptor EP4 subtype
UniProt Synonym Protein Names
Prostanoid EP4 receptor
UniProt Gene Name
PTGER4
UniProt Synonym Gene Names
PTGER2; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype
NCBI Protein Information
prostaglandin E2 receptor EP4 subtype

NCBI Summary for PE2R4

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
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UniProt Comments for PE2R4

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.CautionWas originally designated as the EP2 subtype.
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Research Articles on PE2R4

1. Reprogramming of mammary epithelial cells can result from EP4 -mediated stem cell property transfer by extracellular vesicles/exosomes containing caveolae-associated proteins, between mammary basal and luminal epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PE2R4 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
 Prostanoid Ligand Receptors Pathway antibodies  Prostanoid Ligand Receptors Pathway Diagram

Diseases associated with anti-PE2R4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >81 publications with PE2R4 and Neoplasms
 Inflammation Antibodies  >76 publications with PE2R4 and Inflammation
 Necrosis Antibodies  >46 publications with PE2R4 and Necrosis
 Cardiovascular Diseases Antibodies  >36 publications with PE2R4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >26 publications with PE2R4 and Nervous System Diseases
 Breast Neoplasms Antibodies  >14 publications with PE2R4 and Breast Neoplasms
 Kidney Diseases Antibodies  >13 publications with PE2R4 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >13 publications with PE2R4 and Neoplasms, Experimental
 Pain Antibodies  >11 publications with PE2R4 and Pain
 Lung Neoplasms Antibodies  >10 publications with PE2R4 and Lung Neoplasms

Organs/Tissues associated with anti-PE2R4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >115 publications with PE2R4 and Blood
 Vascular Antibodies  >57 publications with PE2R4 and Vascular
 Kidney Antibodies  >39 publications with PE2R4 and Kidney
 Brain Antibodies  >33 publications with PE2R4 and Brain
 Intestine Antibodies  >27 publications with PE2R4 and Intestine
 Lung Antibodies  >26 publications with PE2R4 and Lung
 Eye Antibodies  >22 publications with PE2R4 and Eye
 Connective Tissue Antibodies  >19 publications with PE2R4 and Connective Tissue
 Liver Antibodies  >18 publications with PE2R4 and Liver
 Skin Antibodies  >15 publications with PE2R4 and Skin
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