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CGK 2 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851659

MBS851659 is an antibody targeting CGK 2. Also known as CGK 2 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CGK 2, Antibody
Full Product Name
CGK 2 Antibody
Product Gene Name
anti-CGK 2 antibody
Product Synonym Names
cGMP-dependent protein kinase 2; EC 2.7.11.12; CGK 2; Cgkii; Type II cGMP-dependent protein kinase; PRKG2; PRKGR2
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
CGK 2 antibody detects endogenous levels of total CGK 2 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
84,398 Da
OMIM
601591
3D Structure
ModBase 3D Structure for Q13237
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human CGK 2.

Product Categories/Family for anti-CGK 2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CGK 2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CGK 2 antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-CGK 2 antibody

Western blot analysis of extracts from HUVEC cells, using CGK 2 antibody.
Anti-CGK 2 Antibody – Cat# MBS851659

Product References and Citations for anti-CGK 2 antibody

Orstavik S., Biochem. Biophys. Res. Commun. 220:759-765(1996). Fujii M., FEBS Lett. 375:263-267(1995). Witczak O., Biochem. Biophys. Res. Commun. 245:113-119(1998).

Other Notes

Small volumes of anti-CGK 2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CGK 2. It may not necessarily be applicable to this product.

NCBI GI #
541866806
NCBI GeneID
5593
NCBI Accession #
NP_001269409.1
UniProt Primary Accession #
Q13237
UniProt Secondary Accession #
O00125; O60916; B4DMX3; E7EPE6
UniProt Related Accession #
Q13237
GenBank Nucleotide #
NM_001282480.1
NCBI Official Full Name
cGMP-dependent protein kinase 2 isoform b
NCBI Official Synonym Full Names
protein kinase cGMP-dependent 2
NCBI Official Symbol
PRKG2
NCBI Official Synonym Symbols
PKG2; cGK2; cGKII; PRKGR2
UniProt Protein Name
cGMP-dependent protein kinase 2
UniProt Synonym Protein Names
cGMP-dependent protein kinase II; cGKII
Protein Family
cGMP-dependent protein kinase
UniProt Gene Name
PRKG2
UniProt Synonym Gene Names
PRKGR2; cGK 2; cGK2; cGKII
NCBI Protein Information
cGMP-dependent protein kinase 2

NCBI Summary for CGK 2

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]
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UniProt Comments for CGK 2

Crucial regulator of intestinal secretion and bone growth (). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation ().
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Research Articles on CGK 2

1. Comparative analysis of the backbone hydrogen/deuterium exchange patterns in PKG II:8-pCPT-cGMP and previously reported PKG Ibeta:cGMP XN structures suggests that the ability of these agonists to activate PKG is related to how effectively they quench dynamics of the cyclic nucleotide binding pocket and the surrounding regions.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CGK 2 antibody

 Reference Product  PubMed Publications
 SOX9 antibody  >6 publications with CGK 2 and SOX9

Pathways associated with anti-CGK 2 antibody

 Products by Pathway  Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nitric Oxide Pathway antibodies  Metabolism Of Nitric Oxide Pathway Diagram

Diseases associated with anti-CGK 2 antibody

 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >7 publications with CGK 2 and Bone Diseases
 Nervous System Diseases Antibodies  >6 publications with CGK 2 and Nervous System Diseases
 Growth Disorders Antibodies  >6 publications with CGK 2 and Growth Disorders
 Aneuploidy Antibodies  >4 publications with CGK 2 and Aneuploidy
 Cardiovascular Diseases Antibodies  >2 publications with CGK 2 and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with CGK 2 and Hypertrophy
 Atherosclerosis Antibodies  >1 publications with CGK 2 and Atherosclerosis
 Heart Diseases Antibodies  >1 publications with CGK 2 and Heart Diseases
 Inflammation Antibodies  >1 publications with CGK 2 and Inflammation
 Liver Neoplasms Antibodies  >1 publications with CGK 2 and Liver Neoplasms

Organs/Tissues associated with anti-CGK 2 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >1 publications with CGK 2 and Testis
 Embryonic Tissue Antibodies  >1 publications with CGK 2 and Embryonic Tissue
 Prostate Antibodies  >1 publications with CGK 2 and Prostate
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