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GPR18 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851794

MBS851794 is an antibody targeting GPR18. Also known as GPR18 Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GPR18, Antibody
Full Product Name
GPR18 Antibody
Product Gene Name
anti-GPR18 antibody
Product Synonym Names
N-arachidonyl glycine receptor; NAGly receptor; G-protein coupled receptor 18; GPCRW
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
GPR18 antibody detects endogenous levels of total GPR18 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
38,134 Da
OMIM
602042
3D Structure
ModBase 3D Structure for Q14330
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human GPR18.

Product Categories/Family for anti-GPR18 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GPR18 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-GPR18 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:10000

Testing Data of anti-GPR18 antibody

Anti-GPR18 Antibody – Cat# MBS851794

Western Blot (WB) of anti-GPR18 antibody

Peptide-+ Western blot analysis of extracts from HT-29 cells, using GPR18 antibody. Immunofluorescence analysis of HeLa cells, using GPR18 antibody.
Anti-GPR18 Antibody, Western Blot (WB) – Cat# MBS851794

Product References and Citations for anti-GPR18 antibody

Gantz I., Genomics 42:462-466(1997). Kohno M., Biochem. Biophys. Res. Commun. 347:827-832(2006). Dunham A., Nature 428:522-528(2004).

Other Notes

Small volumes of anti-GPR18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR18. It may not necessarily be applicable to this product.

NCBI GI #
148235349
NCBI GeneID
2841
NCBI Accession #
NP_001091670.1
UniProt Primary Accession #
Q14330
UniProt Secondary Accession #
Q6GTM3; Q96HI6; Q9H2L2
UniProt Related Accession #
Q14330
GenBank Nucleotide #
NM_001098200.1
NCBI Official Full Name
N-arachidonyl glycine receptor
NCBI Official Synonym Full Names
G protein-coupled receptor 18
NCBI Official Symbol
GPR18
UniProt Protein Name
N-arachidonyl glycine receptor
UniProt Synonym Protein Names
G-protein coupled receptor 18
Protein Family
N-arachidonyl glycine receptor
UniProt Gene Name
GPR18
UniProt Synonym Gene Names
GPCRW; NAGly receptor
NCBI Protein Information
N-arachidonyl glycine receptor

UniProt Comments for GPR18

Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).
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Research Articles on GPR18

1. A novel RvD2-GPR18 resolution axis stimulates human and mouse phagocyte functions to control bacterial infections and promote organ protection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GPR18 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-GPR18 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with GPR18 and Neoplasms
 Edema Antibodies  >1 publications with GPR18 and Edema
 Inflammation Antibodies  >1 publications with GPR18 and Inflammation

Organs/Tissues associated with anti-GPR18 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with GPR18 and Brain
 Testis Antibodies  >1 publications with GPR18 and Testis
 Lymph Antibodies  >1 publications with GPR18 and Lymph
 Lymph Node Antibodies  >1 publications with GPR18 and Lymph Node
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