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CNGA1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851859

MBS851859 is an antibody targeting CNGA1. Also known as CNGA1 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNGA1, Antibody
Full Product Name
CNGA1 Antibody
Product Gene Name
Product Synonym Names
cGMP-gated cation channel alpha 1; CNCG; CNCG1; CNG channel alpha 1; CNG-1; CNG1; Cyclic nucleotide gated channel alpha 1; Cyclic nucleotide gated channel; photoreceptor; Cyclic-nucleotide-gated cation channel 1; Rod photoreceptor cGMP-gated channel alpha subunit
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
CNGA1 antibody detects endogenous levels of total CNGA1 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
86,900 Da
OMIM
123825
3D Structure
ModBase 3D Structure for P29973
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human CNGA1.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CNGA1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CNGA1 antibody
WB: 1:500~1:1000
ELISA: 1:40000

Western Blot (WB) of anti-CNGA1 antibody

Western blot analysis of extracts from HepG2 cells and K562 cells, using CNGA1 antibody.
Anti-CNGA1 Antibody – Cat# MBS851859

Product References and Citations for anti-CNGA1 antibody

Pittler S.J., J. Biol. Chem. 267:6257-6262(1992). Dhallan R.S., J. Neurosci. 12:3248-3256(1992). Ota T., Nat. Genet. 36:40-45(2004).

Other Notes

Small volumes of anti-CNGA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNGA1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cGMP-gated cation channel alpha-1 isoform 2
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 1
NCBI Official Symbol
CNGA1
NCBI Official Synonym Symbols
CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha
UniProt Protein Name
cGMP-gated cation channel alpha-1
UniProt Synonym Protein Names
Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
UniProt Gene Name
CNGA1
UniProt Synonym Gene Names
CNCG; CNCG1; CNG channel alpha-1; CNG-1; CNG1
NCBI Protein Information
cGMP-gated cation channel alpha-1

NCBI Summary for CNGA1

The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
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UniProt Comments for CNGA1

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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