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DOCK1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852017

MBS852017 is an antibody targeting DOCK1. Also known as DOCK1 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DOCK1, Antibody
Full Product Name
DOCK1 Antibody
Product Gene Name
Product Synonym Names
180 kDa protein downstream of CRK; dedicator of cytokinesis protein 1; DOC1; DOCK180
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
DOCK1 antibody detects endogenous levels of total DOCK1 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
215,346 Da
OMIM
601403
3D Structure
ModBase 3D Structure for Q14185
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human DOCK1.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DOCK1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-DOCK1 antibody
WB: 1:500~1:1000
ELISA: 1:40000

Western Blot (WB) of anti-DOCK1 antibody

Western blot analysis of extracts from HeLa cells, using DOCK1 antibody.
Anti-DOCK1 Antibody – Cat# MBS852017

Product References and Citations for anti-DOCK1 antibody

Hasegawa H., Mol. Cell. Biol. 16:1770-1776(1996). Deloukas P., Nature 429:375-381(2004). Matsuda M., J. Biol. Chem. 271:14468-14472(1996).

Other Notes

Small volumes of anti-DOCK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DOCK1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
dedicator of cytokinesis protein 1 isoform 2
NCBI Official Synonym Full Names
dedicator of cytokinesis 1
NCBI Official Symbol
DOCK1
NCBI Official Synonym Symbols
ced5; DOCK180
UniProt Protein Name
Dedicator of cytokinesis protein 1
UniProt Synonym Protein Names
180 kDa protein downstream of CRK; DOCK180
UniProt Gene Name
DOCK1
UniProt Synonym Gene Names
DOCK180
NCBI Protein Information
dedicator of cytokinesis protein 1

NCBI Summary for DOCK1

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
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UniProt Comments for DOCK1

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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