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TCF7 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852028

MBS852028 is an antibody targeting TCF7. Also known as TCF7 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TCF7, Antibody
Full Product Name
TCF7 Antibody
Product Gene Name
anti-TCF7 antibody
Product Synonym Names
Transcription factor 7; T-cell-specific transcription factor 1; TCF-1; T-cell factor 1; TCF7; TCF1
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
TCF7 antibody detects endogenous levels of total TCF7 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
30,291 Da
OMIM
189908
3D Structure
ModBase 3D Structure for P36402
Immunogen
The antiserum was produced against synthesized peptide derived from N-terminal of human TCF7.

Product Categories/Family for anti-TCF7 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TCF7 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-TCF7 antibody
WB: 1:500-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-TCF7 antibody

Western blot analysis of extracts from HUVEC cells, COLO205 cells and 293 cells, using TCF7 antibody.
Anti-TCF7 Antibody – Cat# MBS852028

Product References and Citations for anti-TCF7 antibody

van de Wetering M., EMBO J. 10:123-132(1991). Mayer K., Biochim. Biophys. Acta 1263:169-172(1995). Roose J., Science 285:1923-1926(1999).

Other Notes

Small volumes of anti-TCF7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TCF7. It may not necessarily be applicable to this product.

NCBI GI #
293651582
NCBI GeneID
6932
NCBI Accession #
NP_001128323.2
UniProt Primary Accession #
P36402
UniProt Secondary Accession #
Q86WR9; Q9UKI4; B3KSH3
UniProt Related Accession #
P36402
GenBank Nucleotide #
NM_001134851.3
NCBI Official Full Name
transcription factor 7 isoform 3
NCBI Official Synonym Full Names
transcription factor 7
NCBI Official Symbol
TCF7
NCBI Official Synonym Symbols
TCF-1
UniProt Protein Name
Transcription factor 7
UniProt Synonym Protein Names
T-cell-specific transcription factor 1; T-cell factor 1; TCF-1
Protein Family
Transcription factor
UniProt Gene Name
TCF7
UniProt Synonym Gene Names
TCF1; TCF-7; T-cell factor 1; TCF-1
NCBI Protein Information
transcription factor 7

NCBI Summary for TCF7

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
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UniProt Comments for TCF7

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
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Research Articles on TCF7

1. We demonstrated that the AR-miR-1 axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TCF7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >48 publications with TCF7 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >10 publications with TCF7 and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >9 publications with TCF7 and Carcinoma
 Lymphoma Antibodies  >6 publications with TCF7 and Lymphoma
 Breast Neoplasms Antibodies  >6 publications with TCF7 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with TCF7 and Neoplasms, Experimental
 Inflammation Antibodies  >5 publications with TCF7 and Inflammation
 Necrosis Antibodies  >4 publications with TCF7 and Necrosis
 Liver Diseases Antibodies  >4 publications with TCF7 and Liver Diseases
 Anemia Antibodies  >3 publications with TCF7 and Anemia
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