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Ligand (FAS) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852158

MBS852158 is an antibody targeting FAS. Also known as FAS ligand Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FAS ligand, Antibody
Full Product Name
FAS ligand Antibody
Product Gene Name
anti-FAS antibody
Product Synonym Names
Tumor necrosis factor ligand superfamily member 6; Fas antigen ligand; Fas ligand; CD178 antigen; CD95L protein; Apoptosis antigen ligand; APTL; Tumor necrosis factor ligand superfamily member 6; membrane form; Tumor necrosis factor ligand superfamily member 6; soluble form; FASLG; APT1LG1; FASL; TNFSF6
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
FAS ligand antibody detects endogenous levels of total FAS ligand protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
14,006 Da
OMIM
134638
3D Structure
ModBase 3D Structure for P48023
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human FAS ligand.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FAS antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-FAS antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000

Testing Data of anti-FAS antibody

Peptide-+
Anti-FAS Antibody – Cat# MBS852158

Immunohistochemistry (IHC) of anti-FAS antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using FAS ligand antibody. Western blot analysis of extracts from 293 cellls, using FAS ligand antibody.
Anti-FAS Antibody, Immunohistochemistry (IHC) – Cat# MBS852158

Product References and Citations for anti-FAS antibody

Alderson M.; J. Exp. Med. 181:71-77(1995). Takahashi T., Int. Immunol. 6:1567-1574(1994). Gregory S.G., ure 441:315-321(2006).

Other Notes

Small volumes of anti-FAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FAS. It may not necessarily be applicable to this product.

NCBI GI #
4557329
NCBI GeneID
356
NCBI Accession #
NP_000630.1
UniProt Primary Accession #
P48023
UniProt Secondary Accession #
Q9BZP9
UniProt Related Accession #
P48023
GenBank Nucleotide #
NM_000639.2
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 6 isoform 1
NCBI Official Synonym Full Names
Fas ligand
NCBI Official Symbol
FASLG
NCBI Official Synonym Symbols
APTL; FASL; CD178; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 6
UniProt Synonym Protein Names
Apoptosis antigen ligand; APTL
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
FASLG
UniProt Synonym Gene Names
APT1LG1; CD95L; FASL; TNFSF6; APTL; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA
NCBI Protein Information
tumor necrosis factor ligand superfamily member 6

NCBI Summary for FAS

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
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UniProt Comments for FAS

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).
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Research Articles on FAS

1. The authors observed differential expression of CD95(Fas) in CD27(+) B-cells from cirrhotic patients that was inversely correlated with peripheral CD27(+) B-cell frequency. They conclude that peripheral CD27(+) memory B-cells in cirrhosis exhibit increased sensitivity to Fas-induced apoptosis in an activation-dependent manner to which endotoxin contributes, associated with reduced frequency of circulating memory B-cells.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FAS antibody

 Reference Product  PubMed Publications
 FAS antibody  >3480 publications with FAS and FAS
 FADD antibody  >195 publications with FAS and FADD
 SRC antibody  >24 publications with FAS and SRC
 TNFRSF6B antibody  >20 publications with FAS and TNFRSF6B
 PTPN13 antibody  >16 publications with FAS and PTPN13
 LCK antibody  >11 publications with FAS and LCK
 DAXX antibody  >9 publications with FAS and DAXX
 EGR2 antibody  >8 publications with FAS and EGR2
 EGR3 antibody  >7 publications with FAS and EGR3
 FYN antibody  >6 publications with FAS and FYN

Pathways associated with anti-FAS antibody

 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram

Diseases associated with anti-FAS antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1258 publications with FAS and Neoplasms
 Necrosis Antibodies  >960 publications with FAS and Necrosis
 Inflammation Antibodies  >225 publications with FAS and Inflammation
 Liver Diseases Antibodies  >211 publications with FAS and Liver Diseases
 Nervous System Diseases Antibodies  >164 publications with FAS and Nervous System Diseases
 Hepatitis Antibodies  >127 publications with FAS and Hepatitis
 Drug Toxicity Antibodies  >92 publications with FAS and Drug Toxicity
 Breast Neoplasms Antibodies  >88 publications with FAS and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >88 publications with FAS and Neoplasms, Experimental
 Melanoma Antibodies  >78 publications with FAS and Melanoma

Organs/Tissues associated with anti-FAS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1733 publications with FAS and Blood
 Bone Marrow Antibodies  >114 publications with FAS and Bone Marrow
 Intestine Antibodies  >62 publications with FAS and Intestine
 Prostate Antibodies  >57 publications with FAS and Prostate
 Spleen Antibodies  >54 publications with FAS and Spleen
 Uterus Antibodies  >51 publications with FAS and Uterus
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