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SCN4A Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852164

MBS852164 is an antibody targeting SCN4A. Also known as SCN4A Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SCN4A, Antibody
Full Product Name
SCN4A Antibody
Product Gene Name
anti-SCN4A antibody
Product Synonym Names
Sodium channel protein type 4 subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein skeletal muscle subunit alpha; SkM1; SCN4A
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
SCN4A antibody detects endogenous levels of total SCN4A protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
208,061 Da
OMIM
168300
3D Structure
ModBase 3D Structure for P35499
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human SCN4A.

Product Categories/Family for anti-SCN4A antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SCN4A antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SCN4A antibody
WB: 1:500-1:1000
ELISA: 1:10000

Testing Data #2 of anti-SCN4A antibody

Western blot analysis of extracts from K562 cells, using SCN4A antibody.
Anti-SCN4A Antibody – Cat# MBS852164

Product References and Citations for anti-SCN4A antibody

George A.L. Jr., Ann. Neurol. 31:131-137(1992). Wang J., Biochem. Biophys. Res. Commun. 182:794-801(1992). Tsujino A., Proc. Natl. Acad. Sci. U.S.A. 100:7377-7382(2003).

Other Notes

Small volumes of anti-SCN4A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SCN4A. It may not necessarily be applicable to this product.

NCBI GI #
93587342
NCBI GeneID
6329
NCBI Accession #
NP_000325.4
UniProt Primary Accession #
P35499
UniProt Secondary Accession #
Q15478; Q16447; Q7Z6B1
UniProt Related Accession #
P35499
GenBank Nucleotide #
NM_000334.4
NCBI Official Full Name
sodium channel protein type 4 subunit alpha
NCBI Official Synonym Full Names
sodium voltage-gated channel alpha subunit 4
NCBI Official Symbol
SCN4A
NCBI Official Synonym Symbols
HYPP; SkM1; CMS16; HYKPP; NAC1A; HOKPP2; Nav1.4; Na(V)1.4
UniProt Protein Name
Sodium channel protein type 4 subunit alpha
UniProt Synonym Protein Names
SkM1; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4
Protein Family
Sodium channel protein
UniProt Gene Name
SCN4A
NCBI Protein Information
sodium channel protein type 4 subunit alpha

NCBI Summary for SCN4A

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008]
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UniProt Comments for SCN4A

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.
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Research Articles on SCN4A

1. We identified a novel Nav 1.4 mutation I692M in 14 families out of the 104 genetically identified Hyperkalemic periodic paralysis (HyperPP) families in the Neuromuscular Centre Ulm and is therefore as frequent as I693T (13 families out of 14 HyperPP families) in Germany. Surprisingly, in 13 families, a known polymorphism S906T was also present
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SCN4A antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram

Diseases associated with anti-SCN4A antibody

 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >155 publications with SCN4A and Muscular Diseases
 Myotonia Antibodies  >101 publications with SCN4A and Myotonia
 Hypokalemic Periodic Paralysis Antibodies  >62 publications with SCN4A and Hypokalemic Periodic Paralysis
 HYPOKALEMIC PERIODIC PARALYSIS, TYPE 1 Antibodies  >61 publications with SCN4A and HYPOKALEMIC PERIODIC PARALYSIS, TYPE 1
 Myotonia Congenita Antibodies  >56 publications with SCN4A and Myotonia Congenita
 Paralysis, Hyperkalemic Periodic Antibodies  >54 publications with SCN4A and Paralysis, Hyperkalemic Periodic
 Pain Antibodies  >16 publications with SCN4A and Pain
 Cardiovascular Diseases Antibodies  >15 publications with SCN4A and Cardiovascular Diseases
 Heart Diseases Antibodies  >14 publications with SCN4A and Heart Diseases
 Potassium aggravated myotonia Antibodies  >10 publications with SCN4A and Potassium aggravated myotonia

Organs/Tissues associated with anti-SCN4A antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >288 publications with SCN4A and Muscle
 Brain Antibodies  >20 publications with SCN4A and Brain
 Thyroid Antibodies  >10 publications with SCN4A and Thyroid
 Liver Antibodies  >2 publications with SCN4A and Liver
 Testis Antibodies  >1 publications with SCN4A and Testis
 Placenta Antibodies  >1 publications with SCN4A and Placenta
 Pituitary Gland Antibodies  >1 publications with SCN4A and Pituitary Gland
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