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KLKB1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852268

MBS852268 is an antibody targeting KLKB1. Also known as KLKB1 (heavy chain, Cleaved-Arg390) Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KLKB1, Antibody
Full Product Name
KLKB1 (heavy chain, Cleaved-Arg390) Antibody
Product Gene Name
Product Synonym Names
EC 3.4.21.34; Fletcher factor; kininogenin; KLK3
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
KLKB1 (heavy chain, Cleaved-Arg390) antibody detects endogenous levels of fragment of activated KLKB1 resulting from cleavage adjacent to Arg390.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
71,370 Da
OMIM
229000
3D Structure
ModBase 3D Structure for P03952
Immunogen
The antiserum was produced against synthesized peptide derived from human KLKB1.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KLKB1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-KLKB1 antibody
WB: 1:500-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-KLKB1 antibody

Western blot analysis of extracts from HeLa cells, using KLKB1 (heavy chain, Cleaved-Arg390) antibody.
Anti-KLKB1 Antibody – Cat# MBS852268

Product References and Citations for anti-KLKB1 antibody

Chung D.W., Biochemistry 25:2410-2417(1986). Yu H., Genomics 69:225-234(2000). McMullen B.A., Biochemistry 30:2050-2056(1991).

Other Notes

Small volumes of anti-KLKB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLKB1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
plasma kallikrein isoform 1 preproprotein
NCBI Official Synonym Full Names
kallikrein B1
NCBI Official Symbol
KLKB1
NCBI Official Synonym Symbols
PKK; PPK; KLK3; PKKD
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikrein; PKK
Protein Family
UniProt Gene Name
KLKB1
UniProt Synonym Gene Names
KLK3; PKK
NCBI Protein Information
plasma kallikrein

NCBI Summary for KLKB1

This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
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UniProt Comments for KLKB1

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLKB1 antibody

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