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Keratin 17 (K17) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852435

MBS852435 is an antibody targeting K17. Also known as Keratin 17 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Keratin 17 (K17), Antibody
Full Product Name
Keratin 17 Antibody
Product Gene Name
anti-K17 antibody
Product Synonym Names
Keratin; type I cytoskeletal 17; Cytokeratin-17; CK-17
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
Keratin 17 antibody detects endogenous levels of total keratin 17 protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
48,106 Da
OMIM
148069
3D Structure
ModBase 3D Structure for Q04695
Immunogen
The antiserum was produced against synthesized peptide derived from human keratin 17.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-K17 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-K17 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:20000

Immunohistochemistry (IHC) of anti-K17 antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using keratin 17 antibody.
Anti-K17 Antibody – Cat# MBS852435

Western Blot (WB) of anti-K17 antibody

Western blot analysis of extracts from HuvEc cells, using keratin 17 antibody.
Anti-K17 Antibody, Western Blot (WB) – Cat# MBS852435

Immunofluorescence (IF) of anti-K17 antibody

Peptide-+ Immunofluorescence analysis of HepG2 cells, using keratin 17 antibody.
Anti-K17 Antibody, Immunofluorescence (IF) – Cat# MBS852435

Product References and Citations for anti-K17 antibody

M Rosenberg, Mol. Cell. Biol., Feb 1988; 8: 722-736. SM Troyanovsky, J. Cell Sci., Jul 1989; 93: 419. Kevin M. McGowan, Genes & Dev., Jun 2002; 16: 1412. Nicholas Bianchi, Mol. Cell. Biol., Aug 2005; 25: 7249-7259.

Other Notes

Small volumes of anti-K17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for K17. It may not necessarily be applicable to this product.

NCBI GI #
4557701
NCBI GeneID
3872
NCBI Accession #
NP_000413.1
UniProt Primary Accession #
Q04695
UniProt Secondary Accession #
Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2
UniProt Related Accession #
Q04695
GenBank Nucleotide #
NM_000422.2
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
KRT17
NCBI Official Synonym Symbols
PC; K17; PC2; 39.1; CK-17; PCHC1
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17; K17
Protein Family
Keratin
UniProt Gene Name
KRT17
UniProt Synonym Gene Names
CK-17; K17
NCBI Protein Information
keratin, type I cytoskeletal 17

NCBI Summary for K17

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

UniProt Comments for K17

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
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Research Articles on K17

1. The findings suggest that CK17, although not specific for differentiated vulvar intraepithelial neoplasia (dVIN), when combined with histologic findings, Ki-67, and p53 immunohistochemistry, can be a marker of vulvar dysplasia and serve as an adjunct in the diagnosis of dVIN.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-K17 antibody

 Reference Product  PubMed Publications
 KRT6A antibody  >17 publications with K17 and KRT6A
 KRT7 antibody  >1 publications with K17 and KRT7

Pathways associated with anti-K17 antibody

 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram

Diseases associated with anti-K17 antibody

 Disease Name  Pubmed Publications
 Pachyonychia congenita Jackson Lawler type Antibodies  >20 publications with K17 and Pachyonychia congenita Jackson Lawler type
 Neoplasms Antibodies  >19 publications with K17 and Neoplasms
 Adenocarcinoma Antibodies  >7 publications with K17 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >7 publications with K17 and Carcinoma, Squamous Cell
 Breast Neoplasms Antibodies  >5 publications with K17 and Breast Neoplasms
 Pain Antibodies  >4 publications with K17 and Pain
 Skin Neoplasms Antibodies  >3 publications with K17 and Skin Neoplasms
 Carcinoma, Basal Cell Antibodies  >2 publications with K17 and Carcinoma, Basal Cell
 Esophageal Squamous Cell Carcinoma Antibodies  >2 publications with K17 and Esophageal Squamous Cell Carcinoma
 Precancerous Conditions Antibodies  >1 publications with K17 and Precancerous Conditions

Organs/Tissues associated with anti-K17 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >16 publications with K17 and Skin
 Mouth Antibodies  >3 publications with K17 and Mouth
 Lymph Antibodies  >2 publications with K17 and Lymph
 Mammary Gland Antibodies  >2 publications with K17 and Mammary Gland
 Lymph Node Antibodies  >2 publications with K17 and Lymph Node
 Intestine Antibodies  >1 publications with K17 and Intestine
 Bladder Antibodies  >1 publications with K17 and Bladder
 Prostate Antibodies  >1 publications with K17 and Prostate
 Muscle Antibodies  >1 publications with K17 and Muscle
 Pancreas Antibodies  >1 publications with K17 and Pancreas
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