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GNAT1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852481

MBS852481 is an antibody targeting GNAT1. Also known as GNAT1 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GNAT1, Antibody
Full Product Name
GNAT1 Antibody
Product Gene Name
anti-GNAT1 antibody
Product Synonym Names
GBT1; GNATR; guanine nucleotide-binding protein G; transducin alpha-1 ch
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
GNAT1 antibody detects endogenous levels of total GNAT1 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
40,041 Da
OMIM
139330
3D Structure
ModBase 3D Structure for P11488
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human GNAT1.

Product Categories/Family for anti-GNAT1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GNAT1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-GNAT1 antibody
WB: 1:500~1:1000
ELISA: 1:40000

Western Blot (WB) of anti-GNAT1 antibody

Western blot analysis of extracts from COLO cells, using GNAT1 antibody.
Anti-GNAT1 Antibody – Cat# MBS852481

Product References and Citations for anti-GNAT1 antibody

Fong S.-L.; Nucleic Acids Res. 20:2865-2870(1992). Lerea C.L., Neuron 3:367-376(1989). van Dop C., Nucleic Acids Res. 17:4887-4887(1989).

Other Notes

Small volumes of anti-GNAT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GNAT1. It may not necessarily be applicable to this product.

NCBI GI #
22027520
NCBI GeneID
2779
NCBI Accession #
NP_000163.2
UniProt Primary Accession #
P11488
UniProt Secondary Accession #
Q4VBN2
UniProt Related Accession #
P11488
GenBank Nucleotide #
NM_000172.3
NCBI Official Full Name
guanine nucleotide-binding protein G(t) subunit alpha-1
NCBI Official Synonym Full Names
G protein subunit alpha transducin 1
NCBI Official Symbol
GNAT1
NCBI Official Synonym Symbols
GBT1; GNATR; CSNB1G; CSNBAD3
UniProt Protein Name
Guanine nucleotide-binding protein G(t) subunit alpha-1
UniProt Synonym Protein Names
Transducin alpha-1 chain
UniProt Gene Name
GNAT1
UniProt Synonym Gene Names
GNATR
NCBI Protein Information
guanine nucleotide-binding protein G(t) subunit alpha-1

NCBI Summary for GNAT1

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
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UniProt Comments for GNAT1

Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase ().
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Research Articles on GNAT1

1. These data suggest that some truncating GNAT1 variants can indeed cause a recessive, mild, late-onset retinal degeneration in human beings rather than just stationary night-blindness as reported previously.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GNAT1 antibody

 Products by Pathway  Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G-protein Activation Pathway antibodies  G-protein Activation Pathway Diagram
 G-protein Mediated Events Pathway antibodies  G-protein Mediated Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Opioid Signalling Pathway antibodies  Opioid Signalling Pathway Diagram
 PLC Beta Mediated Events Pathway antibodies  PLC Beta Mediated Events Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-GNAT1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with GNAT1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with GNAT1 and Disease Models, Animal
 Carcinoma Antibodies  >4 publications with GNAT1 and Carcinoma
 Congenital Abnormalities Antibodies  >4 publications with GNAT1 and Congenital Abnormalities
 Neoplasms Antibodies  >4 publications with GNAT1 and Neoplasms
 Central Nervous System Diseases Antibodies  >1 publications with GNAT1 and Central Nervous System Diseases
 Inflammation Antibodies  >1 publications with GNAT1 and Inflammation
 Adenocarcinoma Antibodies  >1 publications with GNAT1 and Adenocarcinoma
 Kidney Diseases Antibodies  >1 publications with GNAT1 and Kidney Diseases

Organs/Tissues associated with anti-GNAT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >80 publications with GNAT1 and Eye
 Brain Antibodies  >6 publications with GNAT1 and Brain
 Muscle Antibodies  >1 publications with GNAT1 and Muscle
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