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Prostate Apoptosis Response Protein-4 (PAR4) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852599

MBS852599 is an antibody targeting PAR4. Also known as Prostate Apoptosis Response Protein-4 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Prostate Apoptosis Response Protein-4 (PAR4), Antibody
Full Product Name
Prostate Apoptosis Response Protein-4 Antibody
Product Gene Name
Product Synonym Names
PRKC apoptosis WT1 regulator protein; PRKC; apoptosis; WT1; regulator; Par-4; WT1-interacting protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4 protein; transcriptional repressor PAR4
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
Prostate Apoptosis Response Protein-4 antibody detects endogenous levels of total prostate apoptosis response protein-4 protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
36,568 Da
OMIM
601936
3D Structure
ModBase 3D Structure for Q96IZ0
Immunogen
The antiserum was produced against synthesized peptide derived from human prostate apoptosis response protein-4.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PAR4 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-PAR4 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000

Immunohistochemistry (IHC) of anti-PAR4 antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Prostate Apoptosis Response Protein-4 antibody.
Anti-PAR4 Antibody – Cat# MBS852599

Western Blot (WB) of anti-PAR4 antibody

Western blot analysis of extracts from NIH/3T3 cells, using Prostate Apoptosis Response Protein-4 antibody.
Anti-PAR4 Antibody, Western Blot (WB) – Cat# MBS852599

Product References and Citations for anti-PAR4 antibody

Hongzhe Li, J. Biol. Chem., Feb 2007; 282: 4943-4950. Wuhan Xiao, Cancer Res., Aug 2003; 63: 4698-4704. Thierry Virolle, J. Biol. Chem., Mar 2003; 278: 11802-11810. Derek J. Richard, Genes & Dev., Feb 2001; 15: 328.

Other Notes

Small volumes of anti-PAR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PAR4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
PRKC apoptosis WT1 regulator protein isoform 1
NCBI Official Synonym Full Names
pro-apoptotic WT1 regulator
NCBI Official Symbol
PAWR
NCBI Official Synonym Symbols
PAR4; Par-4
UniProt Protein Name
PRKC apoptosis WT1 regulator protein
UniProt Synonym Protein Names
Prostate apoptosis response 4 protein; Par-4
UniProt Gene Name
PAWR
UniProt Synonym Gene Names
PAR4; Par-4
NCBI Protein Information
PRKC apoptosis WT1 regulator protein

NCBI Summary for PAR4

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
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UniProt Comments for PAR4

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PAR4 antibody

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