Western blot analysis of extracts from 293 cells untreated or treated with PMA (200nM, 30mins), using synapsin (Ab-9) antibody (Line 1 and 2) and synapsin (phospho-Ser9) antibody (Line 3 and 4).

Synapsin (SYN1) Antibody

Name: SYN1 Antibody; MyBioSource
Brand: MyBioSource
SKU: MBS852905
Price: 380 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852905

MBS852905 is an antibody targeting SYN1. Also known as Synapsin (Phospho-Ser9) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Synapsin (SYN1), Antibody

Full Product Name

Synapsin (Phospho-Ser9) Antibody

Product Gene Name

anti-SYN1 antibody

Product Synonym Names

Synapsin-1

Species Reactivity

Human, Mouse, Rat

Form/Format

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Specificity

synapsin (phospho-Ser9) antibody detects endogenous levels of synapsin only when phosphorylated at serine 9.The antibody is expected to recognize phosphorylated serine 9 of all synapsin isoforms.

Preparation and Storage

Store at-20 degree C for 1 year

Molecular Weight

70,033 Da

OMIM

300491

3D Structure

ModBase 3D Structure for P17600

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human synapsin around the phosphorylation site of serine 9 (R-L-SP-D-S).

All Sites

Human: Ser9
Mouse: Ser9
Rat: Ser9

Product Categories/Family for anti-SYN1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-SYN1 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-SYN1 antibody

WB: 1:500~1:1000
ELISA: 1:20000

Product References and Citations for anti-SYN1 antibody

Diviya Sinha, et, al. (2005) Am J Physiol Renal Physiol; 288: F703-F713. Franco Onofri, et, al. (2000) J. Biol. Chem; 275: 29857. Dario Bonanomi, et, al. (2005) J. Neurosci; 25: 7299-7308. Hiroshi Tokumitsu, et, al. (2005) J. Biol. Chem; 280: 35108-35118.

Other Notes

Small volumes of anti-SYN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SYN1. It may not necessarily be applicable to this product.

NCBI GI #

19924099

NCBI GeneID

6853

NCBI Accession #

NP_008881.2

UniProt Primary Accession #

P17600

UniProt Secondary Accession #

O75825; Q5H9A9; B1AJQ1

UniProt Related Accession #

P17600

GenBank Nucleotide #

NM_006950.3

NCBI Official Full Name

synapsin-1 isoform Ia

NCBI Official Synonym Full Names

synapsin I

NCBI Official Symbol

SYN1

NCBI Official Synonym Symbols

SYNI; SYN1a; SYN1b

UniProt Protein Name

Synapsin-1

UniProt Synonym Protein Names

Brain protein 4.1; Synapsin I

Protein Family

Sister chromatid cohesion 1 protein

UniProt Gene Name

SYN1

NCBI Protein Information

synapsin-1

NCBI Summary for SYN1

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for SYN1

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.

Research Articles on SYN1

1. These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2, in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SYN1 antibody

Reference Product	PubMed Publications
SYN2 antibody	>14 publications with SYN1 and SYN2
SYN3 antibody	>7 publications with SYN1 and SYN3
PAK3 antibody	>1 publications with SYN1 and PAK3

Pathways associated with anti-SYN1 antibody

Products by Pathway	Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
Dopamine Neurotransmitter Release Cycle Pathway antibodies	Dopamine Neurotransmitter Release Cycle Pathway Diagram
Monoamine Transport Pathway antibodies	Monoamine Transport Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Neurotransmitter Release Cycle Pathway antibodies	Neurotransmitter Release Cycle Pathway Diagram
Serotonin Neurotransmitter Release Cycle Pathway antibodies	Serotonin Neurotransmitter Release Cycle Pathway Diagram
Synaptic Vesicle Pathway antibodies	Synaptic Vesicle Pathway Diagram
Transmission Across Chemical Synapses Pathway antibodies	Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-SYN1 antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>9 publications with SYN1 and Mental Disorders
Neoplasms Antibodies	>6 publications with SYN1 and Neoplasms
Brain Diseases Antibodies	>6 publications with SYN1 and Brain Diseases
Central Nervous System Diseases Antibodies	>5 publications with SYN1 and Central Nervous System Diseases
Neurobehavioral Manifestations Antibodies	>4 publications with SYN1 and Neurobehavioral Manifestations
Cognition Disorders Antibodies	>3 publications with SYN1 and Cognition Disorders
Seizures Antibodies	>3 publications with SYN1 and Seizures
Learning Disorders Antibodies	>3 publications with SYN1 and Learning Disorders
Necrosis Antibodies	>3 publications with SYN1 and Necrosis
Memory Disorders Antibodies	>2 publications with SYN1 and Memory Disorders

Organs/Tissues associated with anti-SYN1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>23 publications with SYN1 and Brain
Nerve Antibodies	>6 publications with SYN1 and Nerve
Testis Antibodies	>3 publications with SYN1 and Testis
Placenta Antibodies	>2 publications with SYN1 and Placenta
Eye Antibodies	>2 publications with SYN1 and Eye
Connective Tissue Antibodies	>1 publications with SYN1 and Connective Tissue
Lung Antibodies	>1 publications with SYN1 and Lung