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COPS1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852990

MBS852990 is an antibody targeting COPS1. Also known as COPS1 (Phospho-Ser454) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COPS1, Antibody
Full Product Name
COPS1 (Phospho-Ser454) Antibody
Product Gene Name
Product Synonym Names
COP9 signalosome complex subunit 1; CSN1; G protein pathway suppressor 1; GPS1; GPS1 protein; MFH protein
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificity
COPS1 (Phospho-Ser454) antibody detects endogenous levels of COPS1 only when phosphorylated at serine 454.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
59,050 Da
OMIM
601934
3D Structure
ModBase 3D Structure for Q13098
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human COPS1 around the phosphorylation site of serine 454 (E-G-SP-Q-G).
All Sites
Human: Ser454
Mouse: Ser454
Rat: Ser454
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-COPS1 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-COPS1 antibody
IHC: 1:50-1:100
ELISA: 1:1000

Immunohistochemistry (IHC) of anti-COPS1 antibody

P-peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using COPS1 (Phospho-Ser454) antibody.
Anti-COPS1 Antibody – Cat# MBS852990

Product References and Citations for anti-COPS1 antibody

Spain B.H., Mol. Cell. Biol. 16:6698-6706(1996). Ota T., Nat. Genet. 36:40-45(2004). Seeger M., FASEB J. 12:469-478(1998).

Other Notes

Small volumes of anti-COPS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COPS1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
COP9 signalosome complex subunit 1 isoform 6
NCBI Official Synonym Full Names
G protein pathway suppressor 1
NCBI Official Symbol
GPS1
NCBI Official Synonym Symbols
CSN1; SGN1; COPS1
UniProt Protein Name
COP9 signalosome complex subunit 1
UniProt Synonym Protein Names
G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; Protein MFH
UniProt Gene Name
GPS1
UniProt Synonym Gene Names
COPS1; CSN1; SGN1; Signalosome subunit 1; GPS-1
NCBI Protein Information
COP9 signalosome complex subunit 1

NCBI Summary for COPS1

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

UniProt Comments for COPS1

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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