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PKR1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852992

MBS852992 is an antibody targeting PKR1. Also known as PKR1 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PKR1, Antibody
Full Product Name
PKR1 Antibody
Product Gene Name
anti-PKR1 antibody
Product Synonym Names
Prokineticin receptor 1; PK-R1; G-protein coupled receptor 73; GPR73a; G-protein coupled receptor ZAQ; PROKR1; GPR73; PKR1
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
PKR1 antibody detects endogenous levels of total PKR1 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
44,770 Da
OMIM
607122
3D Structure
ModBase 3D Structure for Q8TCW9
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human PKR1.

Product Categories/Family for anti-PKR1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PKR1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PKR1 antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-PKR1 antibody

Western blot analysis of extracts from COLO cells, using PKR1 antibody.
Anti-PKR1 Antibody – Cat# MBS852992

Product References and Citations for anti-PKR1 antibody

Masuda Y., Biochem. Biophys. Res. Commun. 293:396-402(2002). Soga T., Biochim. Biophys. Acta 1579:173-179(2002). Lin D.C.-H., J. Biol. Chem. 277:19276-19280(2002).

Other Notes

Small volumes of anti-PKR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PKR1. It may not necessarily be applicable to this product.

NCBI GI #
20373179
NCBI GeneID
10887
NCBI Accession #
NP_620414.1
UniProt Primary Accession #
Q8TCW9
UniProt Secondary Accession #
Q53QT9; Q8NFJ7; A5JUU2
UniProt Related Accession #
Q8TCW9
GenBank Nucleotide #
NM_138964.3
NCBI Official Full Name
prokineticin receptor 1
NCBI Official Synonym Full Names
prokineticin receptor 1
NCBI Official Symbol
PROKR1
NCBI Official Synonym Symbols
ZAQ; PKR1; GPR73; PK-R1; GPR73a
UniProt Protein Name
Prokineticin receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73a
Protein Family
V-type ATPase assembly factor
UniProt Gene Name
PROKR1
UniProt Synonym Gene Names
GPR73; PKR1; PK-R1
NCBI Protein Information
prokineticin receptor 1

NCBI Summary for PKR1

This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]
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UniProt Comments for PKR1

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.

Research Articles on PKR1

1. a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL)(P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PKR1 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-PKR1 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >6 publications with PKR1 and Pain
 Neoplasms Antibodies  >4 publications with PKR1 and Neoplasms
 Nervous System Diseases Antibodies  >3 publications with PKR1 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with PKR1 and Inflammation
 Vascular Diseases Antibodies  >3 publications with PKR1 and Vascular Diseases
 Hyperalgesia Antibodies  >3 publications with PKR1 and Hyperalgesia
 Liver Diseases Antibodies  >1 publications with PKR1 and Liver Diseases
 Liver Cirrhosis, Experimental Antibodies  >1 publications with PKR1 and Liver Cirrhosis, Experimental
 Cardiomegaly Antibodies  >1 publications with PKR1 and Cardiomegaly
 Fibrosis Antibodies  >1 publications with PKR1 and Fibrosis

Organs/Tissues associated with anti-PKR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >4 publications with PKR1 and Testis
 Brain Antibodies  >4 publications with PKR1 and Brain
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