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MMP-9 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS852996

MBS852996 is an antibody targeting MMP-9. Also known as MMP-9 Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MMP-9, Antibody
Full Product Name
MMP-9 Antibody
Product Gene Name
anti-MMP-9 antibody
Product Synonym Names
92 kDa gelatinase; 92 kDa type IV collagenase precursor; CLG4B; GELB; Gelatinase B; MM09
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
MMP-9 antibody detects endogenous levels of total MMP-9 protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
78,458 Da
OMIM
120361
3D Structure
ModBase 3D Structure for P14780
Immunogen
The antiserum was produced against synthesized peptide derived from human MMP-9.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MMP-9 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-MMP-9 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000

Immunohistochemistry (IHC) of anti-MMP-9 antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MMP-9 antibody.
Anti-MMP-9 Antibody – Cat# MBS852996

Western Blot (WB) of anti-MMP-9 antibody

Western blot analysis of extracts from HepG2 cells, using MMP-9 antibody.
Anti-MMP-9 Antibody, Western Blot (WB) – Cat# MBS852996

Product References and Citations for anti-MMP-9 antibody

Martin Illemann, Mol. Cancer Res., May 2006; 4: 293-302. Noemi Ramos-DeSimone, J. Biol. Chem., May 1999; 274: 13066. Vandana Iyer, J. Cell Sci., Mar 2005; 118: 1185-1195. Jon R. Backstrom, J. Neurosci., Dec 1996; 16: 7910.

Other Notes

Small volumes of anti-MMP-9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP-9. It may not necessarily be applicable to this product.

NCBI GI #
74272287
NCBI GeneID
4318
NCBI Accession #
NP_004985.2
UniProt Primary Accession #
P14780
UniProt Secondary Accession #
Q3LR70; Q8N725; Q9H4Z1; Q9UCJ9; Q9UCL1; Q9UDK2; B2R7V9
UniProt Related Accession #
P14780
GenBank Nucleotide #
NM_004994.2
NCBI Official Full Name
matrix metalloproteinase-9 preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 9
NCBI Official Symbol
MMP9
NCBI Official Synonym Symbols
GELB; CLG4B; MMP-9; MANDP2
UniProt Protein Name
Matrix metalloproteinase-9
UniProt Synonym Protein Names
92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB
Protein Family
Matrix metalloproteinase
UniProt Gene Name
MMP9
UniProt Synonym Gene Names
CLG4B; MMP-9; GELB
NCBI Protein Information
matrix metalloproteinase-9

NCBI Summary for MMP-9

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
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UniProt Comments for MMP-9

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
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Research Articles on MMP-9

1. We found that overexpression of AEG-1 in PTC was positively correlated with lymph node metastasis and MMP2/9 expression. Knockdown of AEG-1 reduced the capacity of migration and invasion through downregulation of MMP2/9 in thyroid cancer cells. Furthermore, we firstly found that AEG-1 interacted with MMP9 in thyroid cancer cells.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MMP-9 antibody

 Reference Product  PubMed Publications
 MMP7 antibody  >59 publications with MMP-9 and MMP7
 TIMP3 antibody  >52 publications with MMP-9 and TIMP3
 IL8 antibody  >30 publications with MMP-9 and IL8
 MMP10 antibody  >26 publications with MMP-9 and MMP10
 CD44 antibody  >22 publications with MMP-9 and CD44
 COL1A1 antibody  >18 publications with MMP-9 and COL1A1
 CXCL1 antibody  >14 publications with MMP-9 and CXCL1
 THBS1 antibody  >13 publications with MMP-9 and THBS1
 RECK antibody  >13 publications with MMP-9 and RECK
 CXCL5 antibody  >9 publications with MMP-9 and CXCL5

Pathways associated with anti-MMP-9 antibody

 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram

Diseases associated with anti-MMP-9 antibody

 Disease Name  Pubmed Publications
 Neoplasm Invasiveness Antibodies  >213 publications with MMP-9 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >200 publications with MMP-9 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >98 publications with MMP-9 and Breast Neoplasms
 Liver Diseases Antibodies  >91 publications with MMP-9 and Liver Diseases
 Aortic Diseases Antibodies  >68 publications with MMP-9 and Aortic Diseases
 Aortic Aneurysm Antibodies  >60 publications with MMP-9 and Aortic Aneurysm
 Brain Ischemia Antibodies  >52 publications with MMP-9 and Brain Ischemia
 Aortic Aneurysm, Abdominal Antibodies  >51 publications with MMP-9 and Aortic Aneurysm, Abdominal
 Carcinoma, Squamous Cell Antibodies  >49 publications with MMP-9 and Carcinoma, Squamous Cell
 Myocardial Infarction Antibodies  >42 publications with MMP-9 and Myocardial Infarction

Organs/Tissues associated with anti-MMP-9 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >527 publications with MMP-9 and Blood
 Lung Antibodies  >236 publications with MMP-9 and Lung
 Bone Antibodies  >232 publications with MMP-9 and Bone
 Brain Antibodies  >171 publications with MMP-9 and Brain
 Liver Antibodies  >135 publications with MMP-9 and Liver
 Bone Marrow Antibodies  >102 publications with MMP-9 and Bone Marrow
 Connective Tissue Antibodies  >88 publications with MMP-9 and Connective Tissue
 Kidney Antibodies  >86 publications with MMP-9 and Kidney
 Embryonic Tissue Antibodies  >74 publications with MMP-9 and Embryonic Tissue
 Lymph Node Antibodies  >67 publications with MMP-9 and Lymph Node
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