• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Arachidonate 5 Lipoxygenase (ALOX5) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853093

MBS853093 is an antibody targeting ALOX5. Also known as Arachidonate 5 Lipoxygenase (Phospho-Ser271) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Arachidonate 5 Lipoxygenase (ALOX5), Antibody
Full Product Name
Arachidonate 5 Lipoxygenase (Phospho-Ser271) Antibody
Product Gene Name
anti-ALOX5 antibody
Product Synonym Names
5-lipoxygenase; Arachidonate 5-lipoxygenase; EC 1.13.11.34; LOG5; LOX5
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificity
Arachidonate 5 Lipoxygenase (Phospho-Ser271) antibody detects endogenous levels of Arachidonate 5 lipoxygenase only when phosphorylated at serine 271.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
56,291 Da
OMIM
152390
3D Structure
ModBase 3D Structure for P09917
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human Arachidonate 5 lipoxygenase around the phosphorylation site of serine 271 (Q-L-SP-L-E).
All Sites
Human: Ser272
Mouse: Ser272
Rat: Ser271

Product Categories/Family for anti-ALOX5 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ALOX5 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ALOX5 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000

Testing Data of anti-ALOX5 antibody

P-peptide-+
Anti-ALOX5 Antibody – Cat# MBS853093

Immunohistochemistry (IHC) of anti-ALOX5 antibody

Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using Arachidonate 5 Lipoxygenase (Phospho-Ser271) antibody. Western blot analysis of extracts from HuvEc cells, using Arachidonate 5 Lipoxygenase (Phospho-Ser271) antibody.
Anti-ALOX5 Antibody, Immunohistochemistry (IHC) – Cat# MBS853093

Product References and Citations for anti-ALOX5 antibody

RJ Boado, PNAS, Oct 1992; 89: 9044. K Ochi, J. Biol. Chem., May 1983; 258: 5754-5758. N Ueda, J. Biol. Chem., Jun 1986; 261: 7982-7988. Jagadananda Ghosh, PNAS, Oct 1998; 95: 13182.

Other Notes

Small volumes of anti-ALOX5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALOX5. It may not necessarily be applicable to this product.

NCBI GI #
4502057
NCBI GeneID
240
NCBI Accession #
NP_000689.1
UniProt Primary Accession #
P09917
UniProt Secondary Accession #
Q5JQ14; B7ZLS0; E5FPY5; E5FPY7; E5FPY8
UniProt Related Accession #
P09917
GenBank Nucleotide #
NM_000698.4
NCBI Official Full Name
arachidonate 5-lipoxygenase isoform 1
NCBI Official Synonym Full Names
arachidonate 5-lipoxygenase
NCBI Official Symbol
ALOX5
NCBI Official Synonym Symbols
5-LO; 5LPG; LOG5; 5-LOX
UniProt Protein Name
Arachidonate 5-lipoxygenase
Protein Family
Arachidonate 5-lipoxygenase
UniProt Gene Name
ALOX5
UniProt Synonym Gene Names
LOG5; 5-LO; 5-lipoxygenase
NCBI Protein Information
arachidonate 5-lipoxygenase

NCBI Summary for ALOX5

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Show more

UniProt Comments for ALOX5

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Research Articles on ALOX5

1. Data suggest that the co-carcinogens benzidine and hydrogen peroxide induce expression of ALOX5 mRNA and protein in tracheobronchial epithelial cells; the co-carcinogens decrease cell proliferation but enhance apoptosis, actions inhibited by knockdown of ALOX5 by RNA interference. Benzidine appears to undergo metabolic activation to benzidine diimine by ALOX5.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALOX5 antibody

 Reference Product  PubMed Publications
 ALOX5AP antibody  >195 publications with ALOX5 and ALOX5AP
 COTL1 antibody  >9 publications with ALOX5 and COTL1
 MAPKAPK2 antibody  >7 publications with ALOX5 and MAPKAPK2
 GRB2 antibody  >3 publications with ALOX5 and GRB2
 TGFBRAP1 antibody  >1 publications with ALOX5 and TGFBRAP1

Pathways associated with anti-ALOX5 antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 IL-5 Signaling Pathway antibodies  IL-5 Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram

Diseases associated with anti-ALOX5 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >534 publications with ALOX5 and Inflammation
 Neoplasms Antibodies  >305 publications with ALOX5 and Neoplasms
 Asthma Antibodies  >235 publications with ALOX5 and Asthma
 Lung Diseases Antibodies  >220 publications with ALOX5 and Lung Diseases
 Atherosclerosis Antibodies  >112 publications with ALOX5 and Atherosclerosis
 Necrosis Antibodies  >104 publications with ALOX5 and Necrosis
 Edema Antibodies  >94 publications with ALOX5 and Edema
 Drug Toxicity Antibodies  >88 publications with ALOX5 and Drug Toxicity
 Neoplasms, Experimental Antibodies  >51 publications with ALOX5 and Neoplasms, Experimental
 Pain Antibodies  >47 publications with ALOX5 and Pain

Organs/Tissues associated with anti-ALOX5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1091 publications with ALOX5 and Blood
 Lung Antibodies  >243 publications with ALOX5 and Lung
 Brain Antibodies  >120 publications with ALOX5 and Brain
 Muscle Antibodies  >113 publications with ALOX5 and Muscle
 Bone Antibodies  >75 publications with ALOX5 and Bone
 Heart Antibodies  >67 publications with ALOX5 and Heart
 Kidney Antibodies  >64 publications with ALOX5 and Kidney
 Bone Marrow Antibodies  >56 publications with ALOX5 and Bone Marrow
 Intestine Antibodies  >45 publications with ALOX5 and Intestine
 Prostate Antibodies  >37 publications with ALOX5 and Prostate
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000