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HSP105 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853157

MBS853157 is an antibody targeting HSP105. Also known as HSP105 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HSP105, Antibody
Full Product Name
HSP105 Antibody
Product Gene Name
Product Synonym Names
heat shock 105kDa/110kDa protein 1
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
HSP105 antibody detects endogenous levels of total HSP105 protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
97,460 Da
OMIM
610703
3D Structure
ModBase 3D Structure for Q92598
Immunogen
The antiserum was produced against synthesized peptide derived from human HSP105.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-HSP105 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-HSP105 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:10000

Immunohistochemistry (IHC) of anti-HSP105 antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using HSP105 antibody.
Anti-HSP105 Antibody – Cat# MBS853157

Western Blot (WB) of anti-HSP105 antibody

Western blot analysis of extracts from HeLa cells, using HSP105 antibody.
Anti-HSP105 Antibody, Western Blot (WB) – Cat# MBS853157

Immunofluorescence (IF) of anti-HSP105 antibody

Peptide-+ Immunofluorescence analysis of HeLa cells, using HSP105 antibody.
Anti-HSP105 Antibody, Immunofluorescence (IF) – Cat# MBS853157

Product References and Citations for anti-HSP105 antibody

Kunihiko Yasuda, J. Biol. Chem., Dec 1995; 270: 29718. Nobuyuki Yamagishi, Eur. J. Biochem., Aug 2002; 269: 4143. Nobuyuki Yamagishi, J. Biol. Chem., Oct 2004; 279: 41727-41733. Nobuyuki Yamagishi, J. Biochem. (Tokyo), Aug 2002; 132: 271-278.

Other Notes

Small volumes of anti-HSP105 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HSP105. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
heat shock protein 105 kDa isoform 2
NCBI Official Synonym Full Names
heat shock protein family H (Hsp110) member 1
NCBI Official Symbol
HSPH1
NCBI Official Synonym Symbols
HSP105; HSP105A; HSP105B; NY-CO-25
UniProt Protein Name
Heat shock protein 105 kDa
UniProt Synonym Protein Names
Antigen NY-CO-25; Heat shock 110 kDa protein
UniProt Gene Name
HSPH1
UniProt Synonym Gene Names
HSP105; HSP110; KIAA0201
NCBI Protein Information
heat shock protein 105 kDa

NCBI Summary for HSP105

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
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UniProt Comments for HSP105

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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