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PC Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853249

MBS853249 is an antibody targeting PC. Also known as PC Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PC, Antibody
Full Product Name
PC Antibody
Product Gene Name
Product Synonym Names
EC 6.4.1.1; PCB; PYC; Pyruvate carboxylase,mitochondrial; Pyruvic carboxylase
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
PC antibody detects endogenous levels of total PC protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
57,925 Da
OMIM
266150
3D Structure
ModBase 3D Structure for P11498
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human PC.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PC antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-PC antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:40000

Testing Data of anti-PC antibody

Peptide-+
Anti-PC Antibody – Cat# MBS853249

Immunohistochemistry (IHC) of anti-PC antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PC antibody. Western blot analysis of extracts from Jurkat cells, using PC antibody.
Anti-PC Antibody, Immunohistochemistry (IHC) – Cat# MBS853249

Product References and Citations for anti-PC antibody

Wexler I.D., Biochim. Biophys. Acta 1227:46-52(1994). Mackay N., Biochem. Biophys. Res. Commun. 202:1009-1014(1994). Lamhonwah A.-M., Arch. Biochem. Biophys. 254:631-636(1987).

Other Notes

Small volumes of anti-PC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
pyruvate carboxylase, mitochondrial
NCBI Official Synonym Full Names
pyruvate carboxylase
NCBI Official Symbol
PC
NCBI Official Synonym Symbols
PCB
UniProt Protein Name
Pyruvate carboxylase, mitochondrial
UniProt Synonym Protein Names
Pyruvic carboxylase; PCB
UniProt Gene Name
PC
UniProt Synonym Gene Names
PCB
NCBI Protein Information
pyruvate carboxylase, mitochondrial

NCBI Summary for PC

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for PC

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PC antibody

 Reference Product  PubMed Publications
 GOT2 antibody  >1 publications with PC and GOT2
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