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MRC2 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853311

MBS853311 is an antibody targeting MRC2. Also known as MRC2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MRC2, Antibody
Full Product Name
MRC2 Antibody
Product Gene Name
Product Synonym Names
Macrophage mannose receptor 2 [Precursor]; Urokinase receptor-associated protein; Endocytic receptor 180; CD280 antigen; MRC2; ENDO180; KIAA0709; UPARAP
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1mg/ml (lot specific)
Specificity
MRC2 antibody detects endogenous levels of total MRC2 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
OMIM
612264
3D Structure
ModBase 3D Structure for Q9UBG0
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human MRC2.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MRC2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-MRC2 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:20000

Immunohistochemistry (IHC) of anti-MRC2 antibody

Peptide: - / +
Immunohistochemistry analysis of paraffin-embedded human brain tissue using MRC2 antibody.
Rabbit Anti-MRC2 Antibody – Cat# MBS853311

Western Blot (WB)) of anti-MRC2 antibody

Western blot analysis of extracts from 293 cells, using MRC2 antibody.
Rabbit Anti-MRC2 Antibody, Western Blot (WB)) – Cat# MBS853311

Immunofluorescence (IF) of anti-MRC2 antibody

Peptide: - / +
Immunofluorescence analysis of HepG2 cells, using MRC2 antibody.
Rabbit Anti-MRC2 Antibody, Immunofluorescence (IF) – Cat# MBS853311

Product References and Citations for anti-MRC2 antibody

Behrendt N., J. Biol. Chem. 275:1993-2002(2000). Sheikh H., J. Cell Sci. 113:1021-1032(2000). Howard M.J., J. Biol. Chem. 277:32320-32331(2002).

Other Notes

Small volumes of anti-MRC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MRC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
C-type mannose receptor 2
NCBI Official Synonym Full Names
mannose receptor C type 2
NCBI Official Symbol
MRC2
NCBI Official Synonym Symbols
CD280; UPARAP; CLEC13E; ENDO180
UniProt Protein Name
C-type mannose receptor 2
UniProt Synonym Protein Names
C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase-type plasminogen activator receptor-associated protein; UPAR-associated protein; Urokinase receptor-associated protein; CD_antigen: CD280
UniProt Gene Name
MRC2
UniProt Synonym Gene Names
CLEC13E; ENDO180; KIAA0709; UPARAP; UPAR-associated protein; Urokinase receptor-associated protein
NCBI Protein Information
C-type mannose receptor 2

NCBI Summary for MRC2

This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
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UniProt Comments for MRC2

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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