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14-3-3 epsilon Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853430

MBS853430 is an antibody targeting 14-3-3 epsilon. Also known as 14-3-3 epsilon Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
14-3-3 epsilon, Antibody
Full Product Name
14-3-3 epsilon Antibody
Product Gene Name
anti-14-3-3 epsilon antibody
Product Synonym Names
14-3-3E; 143E; KCIP-1,mitochondrial import stimulation factor L subunit; Protein kinase C inhibitor protein-1; YWHAE
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
14-3-3 epsilon antibody detects endogenous levels of total 14-3-3 epsilon protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
26,504 Da
OMIM
605066
3D Structure
ModBase 3D Structure for P62258
Immunogen
The antiserum was produced against synthesized peptide derived from C-terminal of human 14-3-3 epsilon.

Product Categories/Family for anti-14-3-3 epsilon antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-14-3-3 epsilon antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-14-3-3 epsilon antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-14-3-3 epsilon antibody

Western blot analysis of extracts from HepG2 cells and Jurkat cells, using 14-3-3 epsilon antibody.
Anti-14-3-3 epsilon Antibody – Cat# MBS853430

Product References and Citations for anti-14-3-3 epsilon antibody

Conklin D.S., Proc. Natl. Acad. Sci. U.S.A. 92:7892-7896(1995). Jin D.-Y., Nature 382:308-308(1996). Chong S.S., ome Res. 6:735-741(1996).

Other Notes

Small volumes of anti-14-3-3 epsilon antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for 14-3-3 epsilon. It may not necessarily be applicable to this product.

NCBI GI #
5803225
NCBI GeneID
7531
NCBI Accession #
NP_006752.1
UniProt Primary Accession #
P62258
UniProt Secondary Accession #
P29360; P42655; Q4VJB6; Q53XZ5; Q63631; Q7M4R4; B3KY71; D3DTH5
UniProt Related Accession #
P62258
GenBank Nucleotide #
NM_006761.4
NCBI Official Full Name
14-3-3 protein epsilon
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
NCBI Official Symbol
YWHAE
NCBI Official Synonym Symbols
MDS; HEL2; MDCR; KCIP-1; 14-3-3E
UniProt Protein Name
14-3-3 protein epsilon
Protein Family
1-acyl-sn-glycerol-3-phosphate acyltransferase
UniProt Gene Name
YWHAE
UniProt Synonym Gene Names
14-3-3E
NCBI Protein Information
14-3-3 protein epsilon

NCBI Summary for 14-3-3 epsilon

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
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UniProt Comments for 14-3-3 epsilon

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).
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Research Articles on 14-3-3 epsilon

1. results support YWHAE being a risk gene for Major Depressive Disorder in the Han Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-14-3-3 epsilon antibody

 Reference Product  PubMed Publications
 BAD antibody  >3 publications with 14-3-3 epsilon and BAD
 YWHAZ antibody  >3 publications with 14-3-3 epsilon and YWHAZ
 NDEL1 antibody  >2 publications with 14-3-3 epsilon and NDEL1
 CASP3 antibody  >2 publications with 14-3-3 epsilon and CASP3
 YWHAH antibody  >2 publications with 14-3-3 epsilon and YWHAH
 YWHAB antibody  >2 publications with 14-3-3 epsilon and YWHAB
 TOP2A antibody  >2 publications with 14-3-3 epsilon and TOP2A
 NGFRAP1 antibody  >1 publications with 14-3-3 epsilon and NGFRAP1
 KCNH2 antibody  >1 publications with 14-3-3 epsilon and KCNH2
 HSF1 antibody  >1 publications with 14-3-3 epsilon and HSF1

Pathways associated with anti-14-3-3 epsilon antibody

 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with anti-14-3-3 epsilon antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with 14-3-3 epsilon and Neoplasms
 Brain Diseases Antibodies  >8 publications with 14-3-3 epsilon and Brain Diseases
 Classical Lissencephalies and Subcortical Band Heterotopias Antibodies  >8 publications with 14-3-3 epsilon and Classical Lissencephalies and Subcortical Band Heterotopias
 Cardiovascular Diseases Antibodies  >4 publications with 14-3-3 epsilon and Cardiovascular Diseases
 Necrosis Antibodies  >4 publications with 14-3-3 epsilon and Necrosis
 Heart Diseases Antibodies  >3 publications with 14-3-3 epsilon and Heart Diseases
 Inflammation Antibodies  >3 publications with 14-3-3 epsilon and Inflammation
 Kidney Diseases Antibodies  >3 publications with 14-3-3 epsilon and Kidney Diseases
 Seizures Antibodies  >3 publications with 14-3-3 epsilon and Seizures
 Heart Defects, Congenital Antibodies  >2 publications with 14-3-3 epsilon and Heart Defects, Congenital

Organs/Tissues associated with anti-14-3-3 epsilon antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18 publications with 14-3-3 epsilon and Brain
 Heart Antibodies  >5 publications with 14-3-3 epsilon and Heart
 Kidney Antibodies  >4 publications with 14-3-3 epsilon and Kidney
 Nerve Antibodies  >4 publications with 14-3-3 epsilon and Nerve
 Blood Antibodies  >4 publications with 14-3-3 epsilon and Blood
 Vascular Antibodies  >3 publications with 14-3-3 epsilon and Vascular
 Muscle Antibodies  >3 publications with 14-3-3 epsilon and Muscle
 Stomach Antibodies  >2 publications with 14-3-3 epsilon and Stomach
 Eye Antibodies  >2 publications with 14-3-3 epsilon and Eye
 Lymph Node Antibodies  >2 publications with 14-3-3 epsilon and Lymph Node
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