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KCNQ4 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853689

MBS853689 is an antibody targeting KCNQ4. Also known as KCNQ4 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KCNQ4, Antibody
Full Product Name
KCNQ4 Antibody
Product Gene Name
Product Synonym Names
Potassium voltage-gated channel subfamily KQT member 4; Voltage-gated potassium channel subunit Kv7.4; Potassium channel subunit alpha KvLQT4; KQT-like 4
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
KCNQ4 antibody detects endogenous levels of total KCNQ4 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
71,196 Da
OMIM
600101
3D Structure
ModBase 3D Structure for P56696
Immunogen
The antiserum was produced against synthesized peptide derived from C-terminal of human KCNQ4.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KCNQ4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-KCNQ4 antibody
WB: 1:500~1:1000
ELISA: 1:5000

Western Blot (WB) of anti-KCNQ4 antibody

Western blot analysis of extracts from HuvEc cells, using KCNQ4 antibody. For Research Use Only
Anti-KCNQ4 Antibody – Cat# MBS853689

Product References and Citations for anti-KCNQ4 antibody

Kubisch C., Cell 96:437-446(1999). Gregory S.G., Nature 441:315-321(2006). Selyanko A.A., J. Physiol. (Lond.) 522:349-355(2000).

Other Notes

Small volumes of anti-KCNQ4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNQ4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
potassium voltage-gated channel subfamily KQT member 4 isoform a
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily Q member 4
NCBI Official Symbol
KCNQ4
NCBI Official Synonym Symbols
DFNA2; KV7.4; DFNA2A
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 4
UniProt Synonym Protein Names
KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4
UniProt Gene Name
KCNQ4
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 4

NCBI Summary for KCNQ4

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for KCNQ4

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNQ4 antibody

 Reference Product  PubMed Publications
 KCNQ3 antibody  >39 publications with KCNQ4 and KCNQ3
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