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Tyrosinase (TYR) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853725

MBS853725 is an antibody targeting TYR. Also known as Tyrosinase Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tyrosinase, Antibody
Full Product Name
Tyrosinase Antibody
Product Gene Name
Product Synonym Names
EC 1.14.18.1; Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
Tyrosinase antibody detects endogenous levels of total tyrosinase protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
42,914 Da
OMIM
103470
3D Structure
ModBase 3D Structure for P14679
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human tyrosinase.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TYR antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-TYR antibody
WB: 1:500-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-TYR antibody

Western blot analysis of extracts from COS7 cells, treated with UV (30mins), using Tyrosinase antibody.
Anti-TYR Antibody – Cat# MBS853725

Product References and Citations for anti-TYR antibody

Patricia Giraldo, Nucleic Acids Res., Nov 2003; 31: 6290-6305. R Halaban, J. Cell Biol., Aug 1983; 97: 480. Hee-Young Park, J. Biol. Chem., Jun 1999; 274: 16470. BB Fuller, J. Biol. Chem., Mar 1987; 262: 4024-4033.

Other Notes

Small volumes of anti-TYR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TYR. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tyrosinase
NCBI Official Synonym Full Names
tyrosinase
NCBI Official Symbol
TYR
NCBI Official Synonym Symbols
ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
UniProt Protein Name
Tyrosinase
UniProt Synonym Protein Names
LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB
Protein Family
UniProt Gene Name
TYR
NCBI Protein Information
tyrosinase

NCBI Summary for TYR

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
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UniProt Comments for TYR

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TYR antibody

 Reference Product  PubMed Publications
 TYRP1 antibody  >98 publications with TYR and TYRP1
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