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CD226/DNAM-1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853763

MBS853763 is an antibody targeting CD226/DNAM-1. Also known as CD226/DNAM-1 (Ab-329) Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD226/DNAM-1, Antibody
Full Product Name
CD226/DNAM-1 (Ab-329) Antibody
Product Synonym Names
CD226; DNAM1; DNAX accessory molecule-1; PTA1; TLiSA1; adhesion glycoprotein; platelet and T cell activation antigen 1
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
CD226/DNAM-1 (Ab-329) antibody detects endogenous levels of total CD226/DNAM-1 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
38,614 Da
OMIM
605397
3D Structure
ModBase 3D Structure for Q15762
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human CD226/DNAM-1 around the phosphorylation site of serine 329 (T-F-SP-R-R).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD226/DNAM-1 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-CD226/DNAM-1 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:1000

Western Blot (WB) of anti-CD226/DNAM-1 antibody

Peptide-+ Western blot analysis of extracts from 293 cells, treated with PMA (125ng/ml, 30mins), using CD226/DNAM-1 (Ab-329) antibody. Immunofluorescence analysis of HeLa cells, using CD226/DNAM-1 (Ab-329) antibody.
Anti-CD226/DNAM-1 Antibody, Western Blot (WB) – Cat# MBS853763

Product References and Citations for anti-CD226/DNAM-1 antibody

Shibuya A., Immunity 4:573-581(1996). The MGC Project Team; Genome Res. 14:2121-2127(2004). Tahara-Hanaoka S., Int. Immunol. 16:533-538(2004).

Other Notes

Small volumes of anti-CD226/DNAM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD226/DNAM-1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
CD226 antigen isoform a
NCBI Official Synonym Full Names
CD226 molecule
NCBI Official Symbol
CD226
NCBI Official Synonym Symbols
PTA1; DNAM1; DNAM-1; TLiSA1
UniProt Protein Name
CD226 antigen
UniProt Synonym Protein Names
DNAX accessory molecule 1; DNAM-1; CD_antigen: CD226
UniProt Gene Name
CD226
UniProt Synonym Gene Names
DNAM1; DNAM-1
NCBI Protein Information
CD226 antigen

NCBI Summary for CD226/DNAM-1

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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UniProt Comments for CD226/DNAM-1

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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