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PVRL3 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853895

MBS853895 is an antibody targeting PVRL3. Also known as PVRL3 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PVRL3, Antibody
Full Product Name
PVRL3 Antibody
Product Gene Name
Product Synonym Names
CDw113; nectin-3; poliovirus receptor-related protein 3; PRR3
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
PVRL3 antibody detects endogenous levels of total PVRL3 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
54,375 Da
OMIM
607147
3D Structure
ModBase 3D Structure for Q9NQS3
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human PVRL3.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PVRL3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PVRL3 antibody
WB: 1:500-1:1000
ELISA: 1:1000

Western Blot (WB) of anti-PVRL3 antibody

Western blot analysis of extracts from A549 cells, using PVRL3 antibody.
Anti-PVRL3 Antibody – Cat# MBS853895

Product References and Citations for anti-PVRL3 antibody

Reymond N., Gene 255:347-355(2000). Mueller S., J. Biol. Chem. 278-31251-31260(2003). Fujito T., J. Cell Biol. 171:165-173(2005).

Other Notes

Small volumes of anti-PVRL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PVRL3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
nectin-3 isoform 2
NCBI Official Synonym Full Names
nectin cell adhesion molecule 3
NCBI Official Symbol
NECTIN3
NCBI Official Synonym Symbols
PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3
UniProt Protein Name
Nectin-3
UniProt Synonym Protein Names
CDw113; Nectin cell adhesion molecule 3
UniProt Gene Name
NECTIN3
NCBI Protein Information
nectin-3

NCBI Summary for PVRL3

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
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UniProt Comments for PVRL3

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PVRL3 antibody

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