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TCOF1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853940

MBS853940 is an antibody targeting TCOF1. Also known as TCOF1 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TCOF1, Antibody
Full Product Name
TCOF1 Antibody
Product Gene Name
Product Synonym Names
Treacle protein; Treacher Collins syndrome protein; TCOF1
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
TCOF1 antibody detects endogenous levels of total TCOF1 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
144,414 Da
OMIM
154500
3D Structure
ModBase 3D Structure for Q13428
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human TCOF1.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TCOF1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-TCOF1 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000

Testing Data of anti-TCOF1 antibody

Peptide-+
Anti-TCOF1 Antibody – Cat# MBS853940

Immunohistochemistry (IHC) of anti-TCOF1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using TCOF1 antibody. Western blot analysis of extracts from Jurkat cells, using TCOF1 antibody.
Anti-TCOF1 Antibody, Immunohistochemistry (IHC) – Cat# MBS853940

Product References and Citations for anti-TCOF1 antibody

Dixon J., Nat. Genet. 12:130-136(1996). Wise C.A., Proc. Natl. Acad. Sci. U.S.A. 94:3110-3115(1997). So R.B., Gene 328:49-57(2004).

Other Notes

Small volumes of anti-TCOF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TCOF1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
treacle protein isoform b
NCBI Official Synonym Full Names
treacle ribosome biogenesis factor 1
NCBI Official Symbol
TCOF1
NCBI Official Synonym Symbols
TCS; MFD1; TCS1; treacle
UniProt Protein Name
Treacle protein
UniProt Synonym Protein Names
Treacher Collins syndrome protein
Protein Family
UniProt Gene Name
TCOF1
NCBI Protein Information
treacle protein

NCBI Summary for TCOF1

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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UniProt Comments for TCOF1

Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TCOF1 antibody

 Reference Product  PubMed Publications
 NOP56 antibody  >2 publications with TCOF1 and NOP56

Organs/Tissues associated with anti-TCOF1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with TCOF1 and Brain
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