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Integrin Beta4 (ITB4) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS853947

MBS853947 is an antibody targeting ITB4. Also known as Integrin beta4 (Ab-1510) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Integrin beta4 (ITB4), Antibody
Full Product Name
Integrin beta4 (Ab-1510) Antibody
Product Gene Name
Product Synonym Names
CD104 antigen; GP150; integrin beta-4; integrin beta-4C
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
ITGB4 (Ab-1510) antibody detects endogenous levels of total ITGB4 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
106,779 Da
OMIM
147557
3D Structure
ModBase 3D Structure for P16144
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human ITGB4 around the phosphorylation site of tyrosine 1510 (R-D-YP-S-T).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ITB4 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ITB4 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000

Testing Data of anti-ITB4 antibody

Peptide-+
Anti-ITB4 Antibody – Cat# MBS853947

Immunohistochemistry (IHC) of anti-ITB4 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ITGB4 (Ab-1510) antibody. Western blot analysis of extracts from HepG2 cells, treated with PMA (125ng/ml, 30mins), using ITGB4 (Ab-1510) antibody.
Anti-ITB4 Antibody, Immunohistochemistry (IHC) – Cat# MBS853947

Product References and Citations for anti-ITB4 antibody

Suzuki S., EMBO J. 9:757-763(1990). Hogervorst F., EMBO J. 9:765-770(1990). Tamura R.N., J. Cell Biol. 111:1593-1604(1990).

Other Notes

Small volumes of anti-ITB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ITB4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
integrin beta-4 isoform 1
NCBI Official Synonym Full Names
integrin subunit beta 4
NCBI Official Symbol
ITGB4
NCBI Official Synonym Symbols
CD104; GP150
UniProt Protein Name
Integrin beta-4
UniProt Synonym Protein Names
GP150; CD_antigen: CD104
UniProt Gene Name
ITGB4
NCBI Protein Information
integrin beta-4

NCBI Summary for ITB4

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for ITB4

Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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