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Neuropsin (KLK8) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854022

MBS854022 is an antibody targeting KLK8. Also known as Neuropsin (Cleaved-Val33) Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neuropsin (KLK8), Antibody
Full Product Name
Neuropsin (Cleaved-Val33) Antibody
Product Gene Name
Product Synonym Names
Kallikrein-8 [Precursor]; EC 3.4.21.118; hK8; Neuropsin; NP; Ovasin; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein; Serine protease 19; NRPN; PRSS19; TADG14; UNQ283/PRO322
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
Neuropsin (Cleaved-Val33) antibody detects endogenous levels of fragment of activated Neuropsin resulting from cleavage adjacent to Val33.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
3,653 Da
OMIM
605644
3D Structure
ModBase 3D Structure for O60259
Immunogen
The antiserum was produced against synthesized peptide derived from human Neuropsin.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KLK8 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-KLK8 antibody
WB: 1:500-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-KLK8 antibody

Western blot analysis of extracts from Jurkat cells, treated with etoposide (25uM, 24hours), using Neuropsin (Cleaved-Val33) antibody.
Anti-KLK8 Antibody – Cat# MBS854022

Product References and Citations for anti-KLK8 antibody

Yoshida S., Gene 213:9-16(1998). Underwood L.J., Cancer Res. 59:4435-4439(1999). Mitsui S., Eur. J. Biochem. 260:627-634(1999).

Other Notes

Small volumes of anti-KLK8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLK8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
kallikrein-8 isoform 5
NCBI Official Synonym Full Names
kallikrein related peptidase 8
NCBI Official Symbol
KLK8
NCBI Official Synonym Symbols
NP; HNP; NRPN; PRSS19; TADG14
UniProt Protein Name
Kallikrein-8
UniProt Synonym Protein Names
Neuropsin; NP; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein
Protein Family
UniProt Gene Name
KLK8
UniProt Synonym Gene Names
NRPN; PRSS19; TADG14; hK8; NP
NCBI Protein Information
kallikrein-8

NCBI Summary for KLK8

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
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UniProt Comments for KLK8

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KLK8 antibody

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