Western blot analysis of extracts from 293 cells, using ITIH2 (Cleaved-Asp702) antibody.

ITIH2 Antibody

Name: ITIH2 Antibody; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS854219
Price: 380 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854219

MBS854219 is an antibody targeting ITIH2. Also known as ITIH2 (Cleaved-Asp702) Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ITIH2, Antibody

Full Product Name

ITIH2 (Cleaved-Asp702) Antibody

Product Gene Name

anti-ITIH2 antibody

Product Synonym Names

Inter-alpha-trypsin inhibitor heavy chain H2; Inter-alpha-inhibitor heavy chain 2; ITI heavy chain H2; Inter-alpha-trypsin inhibitor complex component II; Serum-derived hyaluronan-associated protein; SHAP; IGHEP2

Species Reactivity

Human

Form/Format

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity

ITIH2 (Cleaved-Asp702) antibody detects endogenous levels of fragment of activated ITIH2 resulting from cleavage adjacent to Asp702.

Preparation and Storage

Store at-20 degree C for 1 year.

Molecular Weight

106,463 Da

OMIM

146640

3D Structure

ModBase 3D Structure for P19823

Immunogen

The antiserum was produced against synthesized peptide derived from human ITIH2.

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-ITIH2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-ITIH2 antibody

WB: 1:500-1:1000
ELISA: 1:10000

Product References and Citations for anti-ITIH2 antibody

Gebhard W., FEBS Lett. 229:63-67(1988). Salier J.-P., Proc. Natl. Acad. Sci. U.S.A. 84:8272-8276(1987). Salier J.-P., Biol. Chem. Hoppe-Seyler 369:15-18(1988).

Other Notes

Small volumes of anti-ITIH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ITIH2. It may not necessarily be applicable to this product.

NCBI GI #

70778918

NCBI GeneID

3698

NCBI Accession #

NP_002207.2

UniProt Primary Accession #

P19823

UniProt Secondary Accession #

Q14659; Q15484; Q5T986

UniProt Related Accession #

P19823

GenBank Nucleotide #

NM_002216.2

NCBI Official Full Name

inter-alpha-trypsin inhibitor heavy chain H2

NCBI Official Synonym Full Names

inter-alpha-trypsin inhibitor heavy chain 2

NCBI Official Symbol

ITIH2

NCBI Official Synonym Symbols

H2P; SHAP

UniProt Protein Name

Inter-alpha-trypsin inhibitor heavy chain H2

UniProt Synonym Protein Names

Inter-alpha-trypsin inhibitor complex component II; Serum-derived hyaluronan-associated protein; SHAP

Protein Family

Inter-alpha-trypsin inhibitor

UniProt Gene Name

ITIH2

UniProt Synonym Gene Names

IGHEP2; ITI heavy chain H2; ITI-HC2; Inter-alpha-inhibitor heavy chain 2; SHAP

NCBI Protein Information

inter-alpha-trypsin inhibitor heavy chain H2

NCBI Summary for ITIH2

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

UniProt Comments for ITIH2

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Research Articles on ITIH2

1. Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITIH2 antibody

Reference Product	PubMed Publications
ATP5C1 antibody	>1 publications with ITIH2 and ATP5C1

Diseases associated with anti-ITIH2 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>2 publications with ITIH2 and Necrosis
Kidney Neoplasms Antibodies	>1 publications with ITIH2 and Kidney Neoplasms
Breast Neoplasms Antibodies	>1 publications with ITIH2 and Breast Neoplasms
Carcinoma Antibodies	>1 publications with ITIH2 and Carcinoma
Lung Neoplasms Antibodies	>1 publications with ITIH2 and Lung Neoplasms
Immune System Diseases Antibodies	>1 publications with ITIH2 and Immune System Diseases
Neoplasms Antibodies	>1 publications with ITIH2 and Neoplasms
Inflammation Antibodies	>1 publications with ITIH2 and Inflammation

Organs/Tissues associated with anti-ITIH2 antibody

Organ/Tissue Name	Pubmed Publications
Stomach Antibodies	>2 publications with ITIH2 and Stomach
Pancreas Antibodies	>2 publications with ITIH2 and Pancreas
Uterus Antibodies	>2 publications with ITIH2 and Uterus
Kidney Antibodies	>1 publications with ITIH2 and Kidney
Brain Antibodies	>1 publications with ITIH2 and Brain
Liver Antibodies	>1 publications with ITIH2 and Liver