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NR2F6 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854230

MBS854230 is an antibody targeting NR2F6. Also known as NR2F6 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NR2F6, Antibody
Full Product Name
NR2F6 Antibody
Product Gene Name
anti-NR2F6 antibody
Product Synonym Names
EAR2; ERBAL2; NR2F6; Orphan nuclear receptor EAR-2; V-erbA related protein EAR-2
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
NR2F6 antibody detects endogenous levels of total NR2F6 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
42,979 Da
OMIM
132880
3D Structure
ModBase 3D Structure for P10588
Immunogen
The antiserum was produced against synthesized peptide derived from N-terminal of human NR2F6.

Product Categories/Family for anti-NR2F6 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NR2F6 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-NR2F6 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:20000

Testing Data of anti-NR2F6 antibody

Peptide-+
Anti-NR2F6 Antibody – Cat# MBS854230

Immunohistochemistry (IHC) of anti-NR2F6 antibody

Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using NR2F6 antibody. Western blot analysis of extracts from HeLa cells, 293 cells and HUVEC cells, using NR2F6 antibody.
Anti-NR2F6 Antibody, Immunohistochemistry (IHC) – Cat# MBS854230

Immunofluorescence (IF) of anti-NR2F6 antibody

Peptide-+ Immunofluorescence analysis of HepG2 cells, using NR2F6 antibody.
Anti-NR2F6 Antibody, Immunofluorescence (IF) – Cat# MBS854230

Product References and Citations for anti-NR2F6 antibody

Miyajima N., Nucleic Acids Res. 16:11057-11074(1988). The MGC Project Team, Genome Res. 14:2121-2127(2004). Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).

Other Notes

Small volumes of anti-NR2F6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NR2F6. It may not necessarily be applicable to this product.

NCBI GI #
20070199
NCBI GeneID
2063
NCBI Accession #
NP_005225.2
UniProt Primary Accession #
P10588
UniProt Secondary Accession #
Q5XGA0; Q6P586; Q9BUE8; B2RC68
UniProt Related Accession #
P10588
GenBank Nucleotide #
NM_005234.3
NCBI Official Full Name
nuclear receptor subfamily 2 group F member 6
NCBI Official Synonym Full Names
nuclear receptor subfamily 2 group F member 6
NCBI Official Symbol
NR2F6
NCBI Official Synonym Symbols
EAR2; EAR-2; ERBAL2
UniProt Protein Name
Nuclear receptor subfamily 2 group F member 6
UniProt Synonym Protein Names
V-erbA-related protein 2; EAR-2
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR2F6
UniProt Synonym Gene Names
EAR2; ERBAL2; EAR-2
NCBI Protein Information
nuclear receptor subfamily 2 group F member 6

UniProt Comments for NR2F6

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
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Research Articles on NR2F6

1. Results identified rs2288539 in NR2F6 gene to be associated with poor overall and disease-free survival of patients with an early-stage non-small cell lung cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR2F6 antibody

 Reference Product  PubMed Publications
 NR2F2 antibody  >7 publications with NR2F6 and NR2F2

Pathways associated with anti-NR2F6 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram

Diseases associated with anti-NR2F6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with NR2F6 and Neoplasms
 Immune System Diseases Antibodies  >3 publications with NR2F6 and Immune System Diseases
 Carcinoma Antibodies  >2 publications with NR2F6 and Carcinoma
 Brain Diseases Antibodies  >1 publications with NR2F6 and Brain Diseases
 Drug Toxicity Antibodies  >1 publications with NR2F6 and Drug Toxicity
 Cardiovascular Diseases Antibodies  >1 publications with NR2F6 and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with NR2F6 and Inflammation
 Hyperplasia Antibodies  >1 publications with NR2F6 and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with NR2F6 and Breast Neoplasms

Organs/Tissues associated with anti-NR2F6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with NR2F6 and Brain
 Liver Antibodies  >3 publications with NR2F6 and Liver
 Nerve Antibodies  >2 publications with NR2F6 and Nerve
 Heart Antibodies  >1 publications with NR2F6 and Heart
 Bone Antibodies  >1 publications with NR2F6 and Bone
 Placenta Antibodies  >1 publications with NR2F6 and Placenta
 Testis Antibodies  >1 publications with NR2F6 and Testis
 Muscle Antibodies  >1 publications with NR2F6 and Muscle
 Kidney Antibodies  >1 publications with NR2F6 and Kidney
 Intestine Antibodies  >1 publications with NR2F6 and Intestine
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