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XRN2 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854241

MBS854241 is an antibody targeting XRN2. Also known as XRN2 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
XRN2, Antibody
Full Product Name
XRN2 Antibody
Product Gene Name
anti-XRN2 antibody
Product Synonym Names
5'-3' exoribonuclease 2; EC 3.1.13.-; DHM1-like protein; DHP protein; XRN2
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
XRN2 antibody detects endogenous levels of total XRN2 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
99,962 Da
OMIM
608851
3D Structure
ModBase 3D Structure for Q9H0D6
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human XRN2.

Product Categories/Family for anti-XRN2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-XRN2 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-XRN2 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:1000

Testing Data of anti-XRN2 antibody

Peptide-+
Anti-XRN2 Antibody – Cat# MBS854241

Immunohistochemistry (IHC) of anti-XRN2 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using XRN2 antibody. Western blot analysis of extracts from COS-7 cells, using XRN2 antibody.
Anti-XRN2 Antibody, Immunohistochemistry (IHC) – Cat# MBS854241

Product References and Citations for anti-XRN2 antibody

Zhang M., Genomics 59:252-254(1999). Li J., DNA Seq. 16:143-146(2005). Wiemann S., Genome Res. 11:422-435(2001).

Other Notes

Small volumes of anti-XRN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for XRN2. It may not necessarily be applicable to this product.

NCBI GI #
964750564
NCBI GeneID
22803
NCBI Accession #
NP_001304889.1
UniProt Primary Accession #
Q9H0D6
UniProt Secondary Accession #
Q3L8N4; Q6KGZ9; Q9BQL1; Q9NTW0; Q9NXS6; Q9UL53
UniProt Related Accession #
Q9H0D6
GenBank Nucleotide #
NM_001317960.1
NCBI Official Full Name
5'-3' exoribonuclease 2 isoform 1
NCBI Official Synonym Full Names
5'-3' exoribonuclease 2
NCBI Official Symbol
XRN2
UniProt Protein Name
5'-3' exoribonuclease 2
UniProt Synonym Protein Names
DHM1-like protein; DHP protein
UniProt Gene Name
XRN2
UniProt Synonym Gene Names
DHP protein
NCBI Protein Information
5'-3' exoribonuclease 2

NCBI Summary for XRN2

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

UniProt Comments for XRN2

Possesses 5'->3' exoribonuclease activity (). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
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Research Articles on XRN2

1. depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-XRN2 antibody

 Reference Product  PubMed Publications
 DOM3Z antibody  >2 publications with XRN2 and DOM3Z
 DCP2 antibody  >1 publications with XRN2 and DCP2

Pathways associated with anti-XRN2 antibody

 Products by Pathway  Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Major Pathway Of RRNA Processing In The Nucleolus And Cytosol antibodies  Major Pathway Of RRNA Processing In The Nucleolus And Cytosol Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram

Diseases associated with anti-XRN2 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >4 publications with XRN2 and Lung Neoplasms
 Liver Diseases Antibodies  >4 publications with XRN2 and Liver Diseases
 Anemia Antibodies  >1 publications with XRN2 and Anemia
 Fibrosis Antibodies  >1 publications with XRN2 and Fibrosis
 Inflammation Antibodies  >1 publications with XRN2 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with XRN2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with XRN2 and Liver Neoplasms

Organs/Tissues associated with anti-XRN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with XRN2 and Liver
 Blood Antibodies  >5 publications with XRN2 and Blood
 Lung Antibodies  >5 publications with XRN2 and Lung
 Brain Antibodies  >5 publications with XRN2 and Brain
 Testis Antibodies  >3 publications with XRN2 and Testis
 Heart Antibodies  >2 publications with XRN2 and Heart
 Eye Antibodies  >1 publications with XRN2 and Eye
 Vascular Antibodies  >1 publications with XRN2 and Vascular
 Intestine Antibodies  >1 publications with XRN2 and Intestine
 Kidney Antibodies  >1 publications with XRN2 and Kidney
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