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KANK2 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854337

MBS854337 is an antibody targeting KANK2. Also known as KANK2 Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KANK2, Antibody
Full Product Name
KANK2 Antibody
Product Gene Name
Product Synonym Names
Ankyrin repeat domain-containing protein 25; SRC-1-interacting protein; SRC1-interacting protein; Matrix-remodeling-associated protein 3
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
KANK2 antibody detects endogenous levels of total KANK2 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
90,044 Da
OMIM
614610
3D Structure
ModBase 3D Structure for Q63ZY3
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human KANK2.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KANK2 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-KANK2 antibody
IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:40000

Testing Data of anti-KANK2 antibody

Peptide-+
Anti-KANK2 Antibody – Cat# MBS854337

Immunohistochemistry (IHC) of anti-KANK2 antibody

Peptide-+ Immunohistochemistry analysis of paraffin-embedded human heart tissue using KANK2 antibody. Immunofluorescence analysis of A549 cells, using KANK2 antibody.
Anti-KANK2 Antibody, Immunohistochemistry (IHC) – Cat# MBS854337

Product References and Citations for anti-KANK2 antibody

Nagase T., DNA Res. 7:143-150(2000). Ota T., Nat. Genet. 36:40-45(2004). Olsen J.V., Cell 127:635-648(2006).

Other Notes

Small volumes of anti-KANK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KANK2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
KN motif and ankyrin repeat domain-containing protein 2 isoform 2
NCBI Official Synonym Full Names
KN motif and ankyrin repeat domains 2
NCBI Official Symbol
KANK2
NCBI Official Synonym Symbols
SIP; MXRA3; PPKWH; NPHS16; ANKRD25
UniProt Protein Name
KN motif and ankyrin repeat domain-containing protein 2
UniProt Synonym Protein Names
Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein
UniProt Gene Name
KANK2
UniProt Synonym Gene Names
ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein; SRC1-interacting protein
NCBI Protein Information
KN motif and ankyrin repeat domain-containing protein 2

NCBI Summary for KANK2

This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]
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UniProt Comments for KANK2

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-KANK2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with KANK2 and Kidney
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