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MYT1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854364

MBS854364 is an antibody targeting MYT1. Also known as MYT1 (Phospho-Ser83) Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MYT1, Antibody
Full Product Name
MYT1 (Phospho-Ser83) Antibody
Product Gene Name
anti-MYT1 antibody
Product Synonym Names
EC 2.7.11.1; kinase Myt1; Kinase MYT1; Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase; MYT1 kinase; Myt1 protein; PKMYT1; PMYT1
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificity
MYT1 (Phospho-Ser83) antibody detects endogenous levels of MYT1 only when phosphorylated at serine 83.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
47,284 Da
OMIM
602474
3D Structure
ModBase 3D Structure for Q99640
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human MYT1 around the phosphorylation site of serine 83 (R-V-SP-F-R).
All Sites
Human: Ser83

Product Categories/Family for anti-MYT1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MYT1 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-MYT1 antibody
IHC: 1:50-1:100
ELISA: 1:5000

Testing Data of anti-MYT1 antibody

P-peptide-+
Anti-MYT1 Antibody – Cat# MBS854364

Immunohistochemistry (IHC) of anti-MYT1 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using MYT1 (Phospho-Ser83) antibody. MYT1 (Phospho-Ser83) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
Anti-MYT1 Antibody, Immunohistochemistry (IHC) – Cat# MBS854364

Product References and Citations for anti-MYT1 antibody

Booher R.N., J. Biol. Chem. 272:22300-22306(1997). Liu F., Mol. Cell. Biol. 17:571-583(1997). Nousiainen M., Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).

Other Notes

Small volumes of anti-MYT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MYT1. It may not necessarily be applicable to this product.

NCBI GI #
386642875
NCBI GeneID
9088
NCBI Accession #
NP_001245379.1
UniProt Primary Accession #
Q99640
UniProt Secondary Accession #
O14731; Q7LE24; Q8TCM9; B3KUN8; B4DXD4; D3DUA4; F8W164; I3L1V2
UniProt Related Accession #
Q99640
GenBank Nucleotide #
NM_001258450.1
NCBI Official Full Name
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3
NCBI Official Synonym Full Names
protein kinase, membrane associated tyrosine/threonine 1
NCBI Official Symbol
PKMYT1
NCBI Official Synonym Symbols
MYT1; PPP1R126
UniProt Protein Name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
UniProt Synonym Protein Names
Myt1 kinase
Protein Family
Myelin transcription factor
UniProt Gene Name
PKMYT1
UniProt Synonym Gene Names
MYT1
NCBI Protein Information
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

NCBI Summary for MYT1

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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UniProt Comments for MYT1

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
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Research Articles on MYT1

1. PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYT1 antibody

 Reference Product  PubMed Publications
 CCNB1 antibody  >9 publications with MYT1 and CCNB1
 CDK1 antibody  >5 publications with MYT1 and CDK1
 CDK2 antibody  >3 publications with MYT1 and CDK2
 PLK1 antibody  >2 publications with MYT1 and PLK1
 PIN1 antibody  >1 publications with MYT1 and PIN1

Pathways associated with anti-MYT1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cyclin A/B1 Associated Events During G2/M Transition Pathway antibodies  Cyclin A/B1 Associated Events During G2/M Transition Pathway Diagram
 Cyclin E Associated Events During G1/S Transition Pathway antibodies  Cyclin E Associated Events During G1/S Transition Pathway Diagram
 G1/S Transition Pathway antibodies  G1/S Transition Pathway Diagram
 G2/M Checkpoints Pathway antibodies  G2/M Checkpoints Pathway Diagram

Diseases associated with anti-MYT1 antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >1 publications with MYT1 and Neoplasm Metastasis
 Glioma Antibodies  >1 publications with MYT1 and Glioma
 Kidney Neoplasms Antibodies  >1 publications with MYT1 and Kidney Neoplasms
 Kidney Diseases Antibodies  >1 publications with MYT1 and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with MYT1 and Breast Neoplasms

Organs/Tissues associated with anti-MYT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with MYT1 and Kidney
 Liver Antibodies  >1 publications with MYT1 and Liver
 Blood Antibodies  >1 publications with MYT1 and Blood
 Brain Antibodies  >1 publications with MYT1 and Brain
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