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GPRC6A Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854392

MBS854392 is an antibody targeting GPRC6A. Also known as GPRC6A Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GPRC6A, Antibody
Full Product Name
GPRC6A Antibody
Product Gene Name
anti-GPRC6A antibody
Product Synonym Names
G protein-coupled receptor; family C; group 6; member A; G-protein coupled receptor 33; GPC6A; GPCR33
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
GPC6A antibody detects endogenous levels of total GPC6A protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
96,526 Da
OMIM
613572
3D Structure
ModBase 3D Structure for Q5T6X5
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human GPC6A.

Product Categories/Family for anti-GPRC6A antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GPRC6A antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-GPRC6A antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:1000

Testing Data of anti-GPRC6A antibody

Anti-GPRC6A Antibody – Cat# MBS854392

Western Blot (WB) of anti-GPRC6A antibody

Peptide-+ Western blot analysis of extracts from Jurkat cells, using GPC6A antibody. Immunofluorescence analysis of MCF-7 cells, using GPC6A antibody.
Anti-GPRC6A Antibody, Western Blot (WB) – Cat# MBS854392

Product References and Citations for anti-GPRC6A antibody

Wellendorph P., Gene 335:37-46(2004). Mungall A.J., Nature 425:805-811(2003). Takeda S., FEBS Lett. 520:97-101(2002).

Other Notes

Small volumes of anti-GPRC6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GPRC6A. It may not necessarily be applicable to this product.

NCBI GI #
556503406
NCBI GeneID
222545
NCBI Accession #
NP_001273283.1
UniProt Primary Accession #
Q5T6X5
UniProt Secondary Accession #
Q6JK43; Q6JK44; Q8NGU8; Q8NHZ9; Q8TDT6
UniProt Related Accession #
Q5T6X5
GenBank Nucleotide #
NM_001286354.1
NCBI Official Full Name
G-protein coupled receptor family C group 6 member A isoform 2
NCBI Official Synonym Full Names
G protein-coupled receptor class C group 6 member A
NCBI Official Symbol
GPRC6A
NCBI Official Synonym Symbols
GPCR; bA86F4.3
UniProt Protein Name
G-protein coupled receptor family C group 6 member A
UniProt Synonym Protein Names
G-protein coupled receptor GPCR33; hGPCR33
Protein Family
G-protein coupled receptor family
UniProt Gene Name
GPRC6A
UniProt Synonym Gene Names
hGPRC6A; hGPCR33
NCBI Protein Information
G-protein coupled receptor family C group 6 member A

NCBI Summary for GPRC6A

Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]
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UniProt Comments for GPRC6A

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
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Research Articles on GPRC6A

1. Human GPRC6A is a functional osteocalcin and testosterone sensing receptor that promotes prostate cancer progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GPRC6A antibody

 Products by Pathway  Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-GPRC6A antibody

 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >6 publications with GPRC6A and Prostatic Diseases
 Abnormalities, Multiple Antibodies  >4 publications with GPRC6A and Abnormalities, Multiple
 Inflammation Antibodies  >3 publications with GPRC6A and Inflammation
 Congenital Abnormalities Antibodies  >2 publications with GPRC6A and Congenital Abnormalities
 Fatty Liver Antibodies  >2 publications with GPRC6A and Fatty Liver
 Neoplasm Metastasis Antibodies  >1 publications with GPRC6A and Neoplasm Metastasis
 Weight Gain Antibodies  >1 publications with GPRC6A and Weight Gain
 Breast Neoplasms Antibodies  >1 publications with GPRC6A and Breast Neoplasms
 Nervous System Malformations Antibodies  >1 publications with GPRC6A and Nervous System Malformations
 Oligospermia Antibodies  >1 publications with GPRC6A and Oligospermia

Organs/Tissues associated with anti-GPRC6A antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >11 publications with GPRC6A and Kidney
 Connective Tissue Antibodies  >9 publications with GPRC6A and Connective Tissue
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