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CRHR1 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854483

MBS854483 is an antibody targeting CRHR1. Also known as CRHR1 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CRHR1, Antibody
Full Product Name
CRHR1 Antibody
Product Gene Name
anti-CRHR1 antibody
Product Synonym Names
Corticotropin releasing factor receptor 1 precursor; Corticotropin-releasing hormone receptor 1; CRF-R; CRF1; CRFR; CRFR1; CRH-R 1; CRHR; CRHR1
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
CRHR1 antibody detects endogenous levels of total CRHR1 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
28,122 Da
OMIM
122561
3D Structure
ModBase 3D Structure for P34998
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human CRHR1.

Product Categories/Family for anti-CRHR1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CRHR1 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-CRHR1 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:5000

Testing Data of anti-CRHR1 antibody

Anti-CRHR1 Antibody – Cat# MBS854483

Western Blot (WB) of anti-CRHR1 antibody

Peptide-+ Western blot analysis of extracts from HT-29 cells, using CRHR1 antibody. Immunofluorescence analysis of MCF-7 cells, using CRHR1 antibody.
Anti-CRHR1 Antibody, Western Blot (WB) – Cat# MBS854483

Product References and Citations for anti-CRHR1 antibody

Chen R., Proc. Natl. Acad. Sci. U.S.A. 90:8967-8971(1993). Vita N., FEBS Lett. 335:1-5(1993). Sakai K., Gene 219:125-130(1998).

Other Notes

Small volumes of anti-CRHR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CRHR1. It may not necessarily be applicable to this product.

NCBI GI #
223717971
NCBI GeneID
1394
NCBI Accession #
NP_001138618.1
UniProt Primary Accession #
P34998
UniProt Secondary Accession #
Q13008; Q4QRJ1; Q9UK64; B4DIE9
UniProt Related Accession #
P34998
GenBank Nucleotide #
NM_001145146.1
NCBI Official Full Name
corticotropin-releasing factor receptor 1 isoform 1
NCBI Official Synonym Full Names
corticotropin releasing hormone receptor 1
NCBI Official Symbol
CRHR1
NCBI Official Synonym Symbols
CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRF-R-1; CRH-R-1
UniProt Protein Name
Corticotropin-releasing factor receptor 1
UniProt Synonym Protein Names
Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
Protein Family
Corticotropin-releasing factor receptor
UniProt Gene Name
CRHR1
UniProt Synonym Gene Names
CRFR; CRFR1; CRHR; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1
NCBI Protein Information
corticotropin-releasing factor receptor 1

NCBI Summary for CRHR1

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]
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UniProt Comments for CRHR1

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
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Research Articles on CRHR1

1. The negative and positive inputs are integrated by hypoxic initiation and duration in CRHR1 transcription.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRHR1 antibody

 Reference Product  PubMed Publications
 CRH antibody  >137 publications with CRHR1 and CRH
 UCN antibody  >14 publications with CRHR1 and UCN
 UCN3 antibody  >5 publications with CRHR1 and UCN3
 CALM1 antibody  >1 publications with CRHR1 and CALM1

Pathways associated with anti-CRHR1 antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-CRHR1 antibody

 Disease Name  Pubmed Publications
 Anxiety Disorders Antibodies  >29 publications with CRHR1 and Anxiety Disorders
 Depressive Disorder Antibodies  >28 publications with CRHR1 and Depressive Disorder
 Nervous System Diseases Antibodies  >21 publications with CRHR1 and Nervous System Diseases
 Depressive Disorder, Major Antibodies  >21 publications with CRHR1 and Depressive Disorder, Major
 Immune System Diseases Antibodies  >16 publications with CRHR1 and Immune System Diseases
 Brain Diseases Antibodies  >14 publications with CRHR1 and Brain Diseases
 Lung Diseases Antibodies  >14 publications with CRHR1 and Lung Diseases
 Inflammation Antibodies  >12 publications with CRHR1 and Inflammation
 Learning Disorders Antibodies  >6 publications with CRHR1 and Learning Disorders
 Drug Toxicity Antibodies  >6 publications with CRHR1 and Drug Toxicity

Organs/Tissues associated with anti-CRHR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >123 publications with CRHR1 and Brain
 Embryonic Tissue Antibodies  >5 publications with CRHR1 and Embryonic Tissue
 Ovary Antibodies  >2 publications with CRHR1 and Ovary
 Eye Antibodies  >2 publications with CRHR1 and Eye
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