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CNOT7 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854889

MBS854889 is an antibody targeting CNOT7. Also known as CNOT7 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CNOT7, Antibody
Full Product Name
CNOT7 Antibody
Product Gene Name
Product Synonym Names
BTG1 binding factor 1; BTG1-binding factor 1; CCR4-NOT transcription complex; 7; CCR4-associated factor 1; carbon catabolite repressor protein (CCR4)-associative factor 1
Species Reactivity
Human, Mouse
Form/Format
Rabbit IgG in phosphate buffered saline(without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antibody was affinity purified from rabbit antisesum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/mL (lot specific)
Specificity
CNOT7 antibody detects endogenous levels of total CNOT7 protein.
Preparation and Storage
Store at-20°C for 1 year.
OMIM
604913
3D Structure
ModBase 3D Structure for Q9UIV1
Immunogen
The antiserum was produced against synthesized peptide derived from N-terminal of human CNOT7.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CNOT7 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CNOT7 antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-CNOT7 antibody

Western blot analysis of extracts from HUVEC cells and HeLa cells, using CNOT7 antibody.
Anti-CNOT7 Antibody – Cat# MBS854889

Product References and Citations for anti-CNOT7 antibody

Bogdan J.A., Biochem. J. 336:471-481(1998). The MGC Project Team; Genome Res. 14:2121-2127(2004).

Other Notes

Small volumes of anti-CNOT7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNOT7. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
CCR4-NOT transcription complex subunit 7 isoform 2
NCBI Official Synonym Full Names
CCR4-NOT transcription complex subunit 7
NCBI Official Symbol
CNOT7
NCBI Official Synonym Symbols
CAF1; CAF-1; Caf1a; hCAF-1
UniProt Protein Name
CCR4-NOT transcription complex subunit 7
UniProt Synonym Protein Names
BTG1-binding factor 1; CCR4-associated factor 1; CAF-1; Caf1a
UniProt Gene Name
CNOT7
UniProt Synonym Gene Names
CAF1; CAF-1
NCBI Protein Information
CCR4-NOT transcription complex subunit 7

NCBI Summary for CNOT7

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
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UniProt Comments for CNOT7

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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