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KCNJ4 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS854912

MBS854912 is an antibody targeting KCNJ4. Also known as KCNJ4 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KCNJ4, Antibody
Full Product Name
KCNJ4 Antibody
Product Gene Name
anti-KCNJ4 antibody
Product Synonym Names
Hippocampal inward rectifier; HIRK2; HRK1; Inward rectifier K channel Kir2.3; Inward rectifier potassium channel 4; IRK4; KCNJ4; Kir2.3; Potassium channel; inwardly rectifying; subfamily J; member 4
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
KCNJ4 antibody detects endogenous levels of total KCNJ4 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
49,500 Da
OMIM
600504
3D Structure
ModBase 3D Structure for P48050
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human KCNJ4.

Product Categories/Family for anti-KCNJ4 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KCNJ4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-KCNJ4 antibody
WB: 1:500~1:1000
ELISA: 1:40000

Testing Data #2 of anti-KCNJ4 antibody

Western blot analysis of extracts from 293 cells and NIH/3T3 cells, using KCNJ4 antibody.
Anti-KCNJ4 Antibody – Cat# MBS854912

Product References and Citations for anti-KCNJ4 antibody

Perier F., Proc. Natl. Acad. Sci. U.S.A. 91:6240-6244(1994). Tang W., FEBS Lett. 348:239-243(1994). Makhina E.N., J. Biol. Chem. 269:20468-20474(1994).

Other Notes

Small volumes of anti-KCNJ4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNJ4. It may not necessarily be applicable to this product.

NCBI GI #
4826798
NCBI GeneID
3761
NCBI Accession #
NP_004972.1
UniProt Primary Accession #
P48050
UniProt Secondary Accession #
Q14D44
UniProt Related Accession #
P48050
GenBank Nucleotide #
NM_004981.1
NCBI Official Full Name
inward rectifier potassium channel 4
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 4
NCBI Official Symbol
KCNJ4
NCBI Official Synonym Symbols
HIR; HRK1; IRK3; HIRK2; IRK-3; Kir2.3
UniProt Protein Name
Inward rectifier potassium channel 4
UniProt Synonym Protein Names
HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel, inwardly rectifying subfamily J member 4
Protein Family
Inward rectifier potassium channel
UniProt Gene Name
KCNJ4
UniProt Synonym Gene Names
IRK3; HIR; IRK-3
NCBI Protein Information
inward rectifier potassium channel 4

NCBI Summary for KCNJ4

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for KCNJ4

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium ().
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Research Articles on KCNJ4

1. Increased excitability and decreased dendritic arborization are associated with downregulation of inward rectifier potassium channels (Kir2.1/2.3).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNJ4 antibody

 Reference Product  PubMed Publications
 KCNJ2 antibody  >7 publications with KCNJ4 and KCNJ2
 PRKCD antibody  >1 publications with KCNJ4 and PRKCD
 DLG1 antibody  >1 publications with KCNJ4 and DLG1
 CASK antibody  >1 publications with KCNJ4 and CASK

Pathways associated with anti-KCNJ4 antibody

 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Classical Kir Channels Pathway antibodies  Classical Kir Channels Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway antibodies  Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram

Diseases associated with anti-KCNJ4 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >6 publications with KCNJ4 and Heart Diseases
 Cardiovascular Diseases Antibodies  >6 publications with KCNJ4 and Cardiovascular Diseases
 Brain Diseases Antibodies  >5 publications with KCNJ4 and Brain Diseases
 Arrhythmias, Cardiac Antibodies  >5 publications with KCNJ4 and Arrhythmias, Cardiac
 Parkinson Disease Antibodies  >3 publications with KCNJ4 and Parkinson Disease
 Hypertension Antibodies  >2 publications with KCNJ4 and Hypertension
 Tachycardia, Ventricular Antibodies  >1 publications with KCNJ4 and Tachycardia, Ventricular

Organs/Tissues associated with anti-KCNJ4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with KCNJ4 and Brain
 Heart Antibodies  >18 publications with KCNJ4 and Heart
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