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SUPT16H Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS855013

MBS855013 is an antibody targeting SUPT16H. Also known as SUPT16H Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SUPT16H, Antibody
Full Product Name
SUPT16H Antibody
Product Gene Name
anti-SUPT16H antibody
Product Synonym Names
CDC68; Chromatin-specific transcription elongation factor 140 kDa subunit; FACT140
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
SUPT16H antibody detects endogenous levels of total SUPT16H protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
119,914 Da
OMIM
605012
3D Structure
ModBase 3D Structure for Q9Y5B9
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human SUPT16H.

Product Categories/Family for anti-SUPT16H antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SUPT16H antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SUPT16H antibody
WB: 1:500-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-SUPT16H antibody

Western blot analysis of extracts from HepG2 cells, using SUPT16H antibody.
Anti-SUPT16H Antibody – Cat# MBS855013

Product References and Citations for anti-SUPT16H antibody

Kang S.-W., Genes Cells 5:251-263(2000). Wada T., Mol. Cell 5:1067-1072(2000). Keller D.M., Mol. Cell 7:283-292(2001).

Other Notes

Small volumes of anti-SUPT16H antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SUPT16H. It may not necessarily be applicable to this product.

NCBI GI #
6005757
NCBI GeneID
11198
NCBI Accession #
NP_009123.1
UniProt Primary Accession #
Q9Y5B9
UniProt Secondary Accession #
Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0
UniProt Related Accession #
Q9Y5B9
GenBank Nucleotide #
NM_007192.3
NCBI Official Full Name
FACT complex subunit SPT16
NCBI Official Synonym Full Names
SPT16 homolog, facilitates chromatin remodeling subunit
NCBI Official Symbol
SUPT16H
NCBI Official Synonym Symbols
CDC68; SPT16; FACTP140; SPT16/CDC68
UniProt Protein Name
FACT complex subunit SPT16
UniProt Synonym Protein Names
Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chromatin transcription complex subunit SPT16; hSPT16
UniProt Gene Name
SUPT16H
UniProt Synonym Gene Names
FACT140; FACTP140; hSPT16
NCBI Protein Information
FACT complex subunit SPT16

NCBI Summary for SUPT16H

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
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UniProt Comments for SUPT16H

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
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Research Articles on SUPT16H

1. present observation and published data suggest that phenotype present in patients with duplication of 14q11.2 region, encompassing the SUPT16H and CHD8 genes, resemble in some extend features described in cases carrying microdeletion of that genomic region

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SUPT16H antibody

 Reference Product  PubMed Publications
 NEK9 antibody  >1 publications with SUPT16H and NEK9

Pathways associated with anti-SUPT16H antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway Diagram
 Formation Of HIV-1 Elongation Complex In The Absence Of HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex In The Absence Of HIV-1 Tat Pathway Diagram
 Formation Of RNA Pol II Elongation Complex Pathway antibodies  Formation Of RNA Pol II Elongation Complex Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 HIV-1 Transcription Elongation Pathway antibodies  HIV-1 Transcription Elongation Pathway Diagram
 HIV-1 Elongation Arrest And Recovery Pathway antibodies  HIV-1 Elongation Arrest And Recovery Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram

Diseases associated with anti-SUPT16H antibody

 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >1 publications with SUPT16H and Heart Defects, Congenital
 Sarcoma Antibodies  >1 publications with SUPT16H and Sarcoma
 Abnormalities, Multiple Antibodies  >1 publications with SUPT16H and Abnormalities, Multiple
 Heart Diseases Antibodies  >1 publications with SUPT16H and Heart Diseases

Organs/Tissues associated with anti-SUPT16H antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with SUPT16H and Muscle
 Heart Antibodies  >1 publications with SUPT16H and Heart
 Blood Antibodies  >1 publications with SUPT16H and Blood
 Lung Antibodies  >1 publications with SUPT16H and Lung
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