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TUSC3 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS855165

MBS855165 is an antibody targeting TUSC3. Also known as TUSC3 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TUSC3, Antibody
Full Product Name
TUSC3 Antibody
Product Gene Name
anti-TUSC3 antibody
Product Synonym Names
Protein N33; Tumor suppressor candidate 3; N33
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
TUSC3 antibody detects endogenous levels of total TUSC3 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
39,558 Da
OMIM
601385
3D Structure
ModBase 3D Structure for Q13454
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human TUSC3.

Product Categories/Family for anti-TUSC3 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TUSC3 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-TUSC3 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:10000

Testing Data of anti-TUSC3 antibody

Anti-TUSC3 Antibody – Cat# MBS855165

Western Blot (WB) of anti-TUSC3 antibody

Peptide-+ Western blot analysis of extracts from HeLa cells and COLO205 cells, using TUSC3 antibody. Immunofluorescence analysis of HeLa cells, using TUSC3 antibody.
Anti-TUSC3 Antibody, Western Blot (WB) – Cat# MBS855165

Product References and Citations for anti-TUSC3 antibody

Macgrogan D., Genomics 35:55-65(1996). The MGC Project Team, Genome Res. 14:2121-2127(2004). Kelleher D.J., Mol. Cell 12:101-111(2003).

Other Notes

Small volumes of anti-TUSC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TUSC3. It may not necessarily be applicable to this product.

NCBI GI #
30410788
NCBI GeneID
7991
NCBI Accession #
NP_006756.2
UniProt Primary Accession #
Q13454
UniProt Secondary Accession #
Q14911; Q14912; Q96FW0; A8MSM0; D3DSP2
UniProt Related Accession #
Q13454
GenBank Nucleotide #
NM_006765.3
NCBI Official Full Name
tumor suppressor candidate 3 isoform a
NCBI Official Synonym Full Names
tumor suppressor candidate 3
NCBI Official Symbol
TUSC3
NCBI Official Synonym Symbols
M33; N33; MRT7; MRT22; MagT2; OST3A; D8S1992
UniProt Protein Name
Tumor suppressor candidate 3
UniProt Synonym Protein Names
Magnesium uptake/transporter TUSC3; Protein N33
Protein Family
Tumor suppressor candidate
UniProt Gene Name
TUSC3
UniProt Synonym Gene Names
N33
NCBI Protein Information
tumor suppressor candidate 3

NCBI Summary for TUSC3

This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]
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UniProt Comments for TUSC3

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.
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Research Articles on TUSC3

1. This paper supports the previous clinical descriptions of the condition caused by TUSC3 mutations and describes the seventh family with mutations in this gene, thus contributing to the genetic spectrum of mutations. This is the first report of a family from the Arabian peninsula with this form of Intellectual disability .
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TUSC3 antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 N-Glycan Biosynthesis Pathway antibodies  N-Glycan Biosynthesis Pathway Diagram
 Oligosaccharyltransferase Pathway antibodies  Oligosaccharyltransferase Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-TUSC3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with TUSC3 and Neoplasms
 Nervous System Diseases Antibodies  >5 publications with TUSC3 and Nervous System Diseases
 Pancreatic Neoplasms Antibodies  >4 publications with TUSC3 and Pancreatic Neoplasms
 Breast Neoplasms Antibodies  >1 publications with TUSC3 and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with TUSC3 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with TUSC3 and Liver Neoplasms

Organs/Tissues associated with anti-TUSC3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with TUSC3 and Blood
 Embryonic Tissue Antibodies  >2 publications with TUSC3 and Embryonic Tissue
 Liver Antibodies  >2 publications with TUSC3 and Liver
 Pancreas Antibodies  >2 publications with TUSC3 and Pancreas
 Brain Antibodies  >2 publications with TUSC3 and Brain
 Bone Antibodies  >1 publications with TUSC3 and Bone
 Heart Antibodies  >1 publications with TUSC3 and Heart
 Lung Antibodies  >1 publications with TUSC3 and Lung
 Eye Antibodies  >1 publications with TUSC3 and Eye
 Placenta Antibodies  >1 publications with TUSC3 and Placenta
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