Rabbit Anti-k-ras Polyclonal Antibody – Cat# MBS855216

k-ras Antibody – Rabbit Polyclonal

Name: k-ras Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS855216
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS855216

Rabbit polyclonal k-ras (1) antibody was raised against a peptide near intermediate residues of human k-ras protein. More details

$430 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

k-ras, Polyclonal Antibody

Full Product Name

k-ras Antibody

Product Gene Name

anti-k-ras antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Purified by peptide affinity column containing 2% BSA and 0.02% NaN3

Preparation and Storage

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.

Molecular Weight

21,425 Da

OMIM

190070

3D Structure

ModBase 3D Structure for P01116

Product Categories/Family for anti-k-ras antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-k-ras antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-k-ras antibody

Peptide ELISA: 1:20,000-1:80,000
WB: 1:200-1,000

Product References and Citations for anti-k-ras antibody

(1) Estrada, P., Rojas-Atencio, A., Zabala, W., et al. Frequency and clinicopathological associations of K-ras mutations in Venezuelan patients with colo-rectal cancer. Invest Clin 50 (1), 55-63 (2009).

Other Notes

Small volumes of anti-k-ras antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for k-ras purchase

MBS855216 is an antibody targeting k-ras. Also known as k-ras Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for k-ras. It may not necessarily be applicable to this product.

NCBI GI #

15718763

NCBI GeneID

3845

NCBI Accession #

NP_203524.1

UniProt Primary Accession #

P01116

UniProt Secondary Accession #

P01118; Q96D10; A8K8Z5; B0LPF9

UniProt Related Accession #

P01116

GenBank Nucleotide #

NM_033360.3

NCBI Official Full Name

GTPase KRas isoform a

NCBI Official Synonym Full Names

KRAS proto-oncogene, GTPase

NCBI Official Symbol

KRAS

NCBI Official Synonym Symbols

NS; NS3; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; c-Ki-ras2

UniProt Protein Name

GTPase KRas

UniProt Synonym Protein Names

K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras

Protein Family

Kinase suppressor of Ras

UniProt Gene Name

KRAS

UniProt Synonym Gene Names

KRAS2; RASK2

NCBI Protein Information

GTPase KRas

NCBI Summary for k-ras

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

UniProt Comments for k-ras

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).

Research Articles on k-ras

1. k-RAS gene mutation status was associated with the response of Gefitinib treatment in patients with nonsmall-cell lung cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-k-ras antibody

Reference Product	PubMed Publications
EGFR antibody	>2739 publications with k-ras and EGFR
PIK3CA antibody	>1031 publications with k-ras and PIK3CA
TP53 antibody	>873 publications with k-ras and TP53
PTPN11 antibody	>177 publications with k-ras and PTPN11
MAP2K1 antibody	>138 publications with k-ras and MAP2K1
SOS1 antibody	>112 publications with k-ras and SOS1
RAF1 antibody	>97 publications with k-ras and RAF1
BCL2 antibody	>44 publications with k-ras and BCL2
RALGDS antibody	>43 publications with k-ras and RALGDS
ARAF antibody	>12 publications with k-ras and ARAF

Pathways associated with anti-k-ras antibody

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Diseases associated with anti-k-ras antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>3668 publications with k-ras and Carcinoma
Colorectal Neoplasms Antibodies	>2599 publications with k-ras and Colorectal Neoplasms
Adenocarcinoma Antibodies	>2458 publications with k-ras and Adenocarcinoma
Lung Neoplasms Antibodies	>1757 publications with k-ras and Lung Neoplasms
Carcinogenesis Antibodies	>1691 publications with k-ras and Carcinogenesis
Pancreatic Neoplasms Antibodies	>893 publications with k-ras and Pancreatic Neoplasms
Carcinoma, Non-Small-Cell Lung Antibodies	>870 publications with k-ras and Carcinoma, Non-Small-Cell Lung
Neoplasm Metastasis Antibodies	>848 publications with k-ras and Neoplasm Metastasis
Neoplasms, Experimental Antibodies	>636 publications with k-ras and Neoplasms, Experimental
Disease Models, Animal Antibodies	>586 publications with k-ras and Disease Models, Animal

Organs/Tissues associated with anti-k-ras antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>2282 publications with k-ras and Lung
Blood Antibodies	>971 publications with k-ras and Blood
Liver Antibodies	>656 publications with k-ras and Liver
Skin Antibodies	>436 publications with k-ras and Skin
Pancreas Antibodies	>430 publications with k-ras and Pancreas
Vascular Antibodies	>420 publications with k-ras and Vascular
Brain Antibodies	>327 publications with k-ras and Brain
Lymph Antibodies	>279 publications with k-ras and Lymph
Lymph Node Antibodies	>278 publications with k-ras and Lymph Node
Bone Antibodies	>241 publications with k-ras and Bone