Mouse Anti-TFEB Monoclonal Antibody – Cat# MBS855668

TFEB Antibody – Mouse Monoclonal

Name: TFEB Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS855668
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS855668

Purified mouse monoclonal antibody generated using E Coli expressed recombinant protein TFEB as immunogen. More details

$455 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TFEB, Monoclonal Antibody

Full Product Name

TFEB Antibody

Product Gene Name

anti-TFEB antibody

Clonality

Monoclonal

Isotype

IgG1

Host

Mouse

Form/Format

Each vial contains 100 ug IgG in 100 ul of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.

Specificity

Anti-TFEB recognizes TFEB expression in Hela whole cell lysate.

Preparation and Storage

The antibody may be stored at-20 degree C for one year in its original formulation. Additionally, antibody may be stored at 2 degree C to 8 degree C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.

Molecular Weight

43,803 Da

OMIM

600744

3D Structure

ModBase 3D Structure for P19484

Immunogen

Recombinant protein corresponding to full length TFEB.

Product Categories/Family for anti-TFEB antibody

Plant antibody

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-TFEB antibody

ELISA (EIA), Western Blot (WB-Ce)

Other Notes

Small volumes of anti-TFEB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFEB purchase

Dysfunctional lysosomes and cellular degradative pathways are causative factors in multiple diseases. Human TFEB is considered a master controlling transcription factor regulating these biosynthetic processes. Further clarification of TFEB localization in cells requires stringent cell biology applications which rely on antibody based techniques. MyBiosource supplies a TFEB antibody from Novus Biologicals to fill this need. With high species reactivity, human, this mouse monoclonal anti TFEB antibody is the clear product of choice for human applications Western blot WB ELISA or IHC over competing rabbit polyclonal primary antibodies for transcription factor EB. Our TFEB antibodies are easily detected with rabbit IgG ALEXA 174 fluor or goat AMP labeled secondary antibodies to save previous protein sample lysates. This TFEB antibody chip grade may be combined with appropriate rabbit polyclonal species in solid phase chip or ELISA tested applications as validated in multiple cell lines. Order 0 1 mg in stabilized buffer today.

Additional Details

NCBI/Uniprot data below describe general gene information for TFEB. It may not necessarily be applicable to this product.

NCBI GI #

24307933

NCBI GeneID

7942

NCBI Accession #

NP_009093.1

UniProt Primary Accession #

P19484

UniProt Secondary Accession #

Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8

UniProt Related Accession #

P19484

GenBank Nucleotide #

NM_007162

NCBI Official Full Name

transcription factor EB isoform 1

NCBI Official Synonym Full Names

transcription factor EB

NCBI Official Symbol

TFEB

NCBI Official Synonym Symbols

TCFEB; BHLHE35; ALPHATFEB

UniProt Protein Name

Transcription factor EB

UniProt Synonym Protein Names

Class E basic helix-loop-helix protein 35; bHLHe35

Protein Family

Transcription factor

UniProt Gene Name

TFEB

UniProt Synonym Gene Names

BHLHE35; bHLHe35

NCBI Protein Information

transcription factor EB

UniProt Comments for TFEB

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Research Articles on TFEB

1. MAP4K3 is identified as an amino acid-dependent regulator of autophagy through its phosphorylation of transcription factor EB (TFEB), a transcriptional activator of autophagy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TFEB antibody

Reference Product	PubMed Publications
TFE3 antibody	>67 publications with TFEB and TFE3
MITF antibody	>43 publications with TFEB and MITF
TFEC antibody	>18 publications with TFEB and TFEC
PRCC antibody	>10 publications with TFEB and PRCC
CTSK antibody	>4 publications with TFEB and CTSK
WT1 antibody	>2 publications with TFEB and WT1
SMAD7 antibody	>1 publications with TFEB and SMAD7

Diseases associated with anti-TFEB antibody

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>45 publications with TFEB and Kidney Diseases
Adenocarcinoma Antibodies	>42 publications with TFEB and Adenocarcinoma
Death Antibodies	>20 publications with TFEB and Death
Nervous System Diseases Antibodies	>20 publications with TFEB and Nervous System Diseases
Brain Diseases Antibodies	>13 publications with TFEB and Brain Diseases
Heart Diseases Antibodies	>8 publications with TFEB and Heart Diseases
Congenital Abnormalities Antibodies	>6 publications with TFEB and Congenital Abnormalities
Liver Diseases Antibodies	>6 publications with TFEB and Liver Diseases
Lung Diseases Antibodies	>5 publications with TFEB and Lung Diseases
Necrosis Antibodies	>5 publications with TFEB and Necrosis

Organs/Tissues associated with anti-TFEB antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>48 publications with TFEB and Kidney
Blood Antibodies	>18 publications with TFEB and Blood
Muscle Antibodies	>12 publications with TFEB and Muscle
Brain Antibodies	>10 publications with TFEB and Brain
Lung Antibodies	>8 publications with TFEB and Lung
Placenta Antibodies	>8 publications with TFEB and Placenta
Bone Antibodies	>8 publications with TFEB and Bone
Eye Antibodies	>5 publications with TFEB and Eye
Lymph Antibodies	>3 publications with TFEB and Lymph
Lymph Node Antibodies	>3 publications with TFEB and Lymph Node