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E-Cadherin (CDH1) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS856968

Cadherins are calcium-dependent cell adhesion proteins. The classic cadherin subfamily includes N-, P-, R-, B-and E-cadherins as well as about ten other members which are found in adherens junctions (AJ), E-cadherin is found at the junctions of epithelial… More details

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Product Overview

Online Datasheet in PDF
Product Name
E-Cadherin (Cdh1), Polyclonal Antibody
Full Product Name
E-Cadherin Antibody
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Species Reactivity
Mouse, Human
Form/Format
Liquid; 1*TBS (pH7.4), 0.5BSA, 25% Glycerol
Purity/Purification
Immunogen affinity purified
Concentration
100ul, 0.45mg/ml (lot specific)
Specificity
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of outside membrane of E-Cadherin.
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
80-124kDa
3D Structure
ModBase 3D Structure for P09803
Preservative
0.05% Sodium Azide.
Cellular Localization
Cell Membrane
Positive Control
A431
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-Cdh1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-Cdh1 antibody
WB: 1:500

Testing Data of anti-Cdh1 antibody

Fig: Western blot analysis on A431 using anti-E-Cadherin polyclonal antibody
Anti-CDH1 Polyclonal Antibody – Cat# MBS856968

Product References and Citations for anti-Cdh1 antibody

1. Ponta H, Hofmann M & Herrlich P. Recent advances in the genetics of metastasis. Eur J Cancer, 1.94, 3.A(1.):1.95. 2. Mareel M, Bracke M & VanRoy F. Cancer metastasis: negative regulation by an invasion-suppressor complex. Cancer Detect Prev, 1.95, 1.(5):451. 3. Nagufuchi A, Shirayoshi Y, Okazaki K, et al. Transformation of cell adhesion properties by exogenously introduced E-cadherindherin cDNA. Nature, 1.87, 3.(61.7):3.1.

Other Notes

Small volumes of anti-Cdh1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cdh1 purchase

MBS856968 is an antibody targeting Cdh1. Also known as E-Cadherin Antibody. Reactive in Mouse, Human.

Additional Details

NCBI/Uniprot data below describe general gene information for Cdh1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cadherin-1 preproprotein
NCBI Official Synonym Full Names
cadherin 1
NCBI Official Symbol
Cdh1
NCBI Official Synonym Symbols
Um; UVO; Ecad; ARC-1; E-cad; L-CAM; AA960649
UniProt Protein Name
Cadherin-1
UniProt Synonym Protein Names
ARC-1; Epithelial cadherin; E-cadherin
UniProt Gene Name
Cdh1
UniProt Synonym Gene Names
E-cadherin
NCBI Protein Information
cadherin-1

NCBI Summary for Cdh1

This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]
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UniProt Comments for Cdh1

Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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